Orioles vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for April 10

Odds updated as of 2:12 a.m.

On Friday in MLB, the Baltimore Orioles are playing the San Francisco Giants.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Orioles vs Giants Game Info

• Baltimore Orioles (6-6) vs. San Francisco Giants (5-8)
• Date: Friday, April 10, 2026
• Time: 7:15 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: Apple TV+

Orioles vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-126) | SF: (+108)
• Spread: BAL: -1.5 (+162) | SF: +1.5 (-196)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Orioles vs Giants Probable Starting Pitchers

Probable Pitchers: Shane Baz (Orioles) - 0-0, 4.09 ERA vs Landen Roupp (Giants) - 1-1, 4.22 ERA

This contest's pitching matchup is set, as the Orioles will send Shane Baz to the mound, while Landen Roupp (1-1) will take the ball for the Giants. Baz has a record of 1-1-0 ATS in two starts with a spread this season. Baz's team won his only start as a favorite this season. Roupp has started two games with set spreads, and the Giants failed to cover in both chances. The Giants were the moneyline underdog for one Roupp start this season -- they won.

Orioles vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (52.6%)

Orioles vs Giants Moneyline

• The moneyline numbers for Orioles vs. Giants reveal Baltimore as the favorite (-126) and San Francisco as the underdog (+108) on the road.

Orioles vs Giants Spread

• The Orioles are hosting the Giants and are favored by 1.5 runs (+162 to cover) on the runline. San Francisco is -196 to cover.

Orioles vs Giants Over/Under

• The Orioles-Giants game on April 10 has been given an over/under of 8.5 runs. The over is set at -110 and the under at -110.

Bet on Baltimore Orioles vs. San Francisco Giants on FanDuel today!

Orioles vs Giants Betting Trends

• The Orioles have been favorites in nine games this season and have come away with the win six times (66.7%) in those contests.
• Baltimore has a record of 5-2 when favored by -126 or more this year.
• The Orioles and their opponents have hit the over in six of their 12 games with a total set by oddsmakers this season.
• The Orioles have posted a record of 4-8-0 against the spread this season.
• The Giants have compiled a 4-6 record in games they were the underdog on the moneyline (winning 40% of those games).
• San Francisco has a 2-3 record (winning 40% of its games) when it has played as a moneyline underdog of +108 or longer.
• The Giants have played in 13 games with an over/under set, and have combined with their opponents to go over the total five times (5-5-3).
• The Giants have covered just 30.8% of their games this season, going 4-9-0 ATS.

Orioles Player Leaders

• Taylor Ward leads Baltimore with 18 hits and an OBP of .464, plus a team-best slugging percentage of .574. He's batting .383.
• Among all qualifying hitters in baseball, he ranks fourth in batting average, sixth in on-base percentage, and 18th in slugging.
• Ward has recorded at least one hit in four straight games. During his last five outings he is batting .450 with six doubles, three walks and three RBIs.
• Gunnar Henderson has three doubles, four home runs and six walks. He's batting .245 and slugging .551 with an on-base percentage of .339.
• Among qualifying hitters, he ranks 78th in batting average, 74th in on-base percentage and 26th in slugging percentage.
• Henderson brings a three-game streak with at least one hit into this one. In his last five games he is hitting .263 with a double, two home runs, four walks and three RBIs.
• Tyler O'Neill has seven hits this season and has a slash line of .241/.353/.345.
• O'Neill has picked up a hit in four straight games. In his last five games he is batting .333 with a walk and an RBI.
• Adley Rutschman has been key for Baltimore with seven hits, an OBP of .353 plus a slugging percentage of .379.

Giants Player Leaders

• Luis Arraez has accumulated a slugging percentage of .420, a team-high for the Giants. He's batting .320 with an on-base percentage of .333.
• Including all qualified hitters in the big leagues, he is 23rd in batting average, 76th in on-base percentage and 74th in slugging percentage.
• Arraez hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .333 with a triple, a walk and three RBIs.
• Matt Chapman's 15 hits and .352 OBP both lead his team. He has a batting average of .300 while slugging .460.
• Including all qualified hitters, his batting average puts him 33rd, his on-base percentage is 62nd, and he is 52nd in slugging.
• Willy Adames has 13 hits, a team-high for the Giants.
• Rafael Devers has a double, two home runs and four walks while batting .220.

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