Odds updated as of 1:12 PM

Wednesday's slate in the MLB includes a matchup between the Baltimore Orioles and the St. Louis Cardinals.

We've got you covered, in terms of the vital information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Cardinals Game Info

• Baltimore Orioles (29-16) vs. St. Louis Cardinals (21-26)
• Date: Wednesday, May 22, 2024
• Time: 1:15 PM ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: MASN2

Orioles vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-126) | STL: (+108)
• Spread: BAL: -1.5 (+125) | STL: +1.5 (-150)
• Total: 9 -- Over: (-110) | Under: (-110)

Orioles vs Cardinals Probable Starting Pitchers

Probable Pitchers: John Means (Orioles) - 2-0, 3.06 ERA vs Kyle Gibson (Cardinals) - 3-2, 4.09 ERA

The probable pitchers are John Means (2-0) for the Orioles and Kyle Gibson (3-2) for the Cardinals. Means and his team are 1-2-0 ATS this season when he starts. Means' team is 2-0 this season when he starts and they're favored on the moneyline. The Cardinals have a 4-5-0 record against the spread in Gibson's starts. The Cardinals have been the moneyline underdog in five of Gibson's starts this season, and they went 2-3 in those games.

Orioles vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (55.1%)

Orioles vs Cardinals Moneyline

• Baltimore is the favorite, -126 on the moneyline, while St. Louis is a +108 underdog despite being at home.

Orioles vs Cardinals Spread

• The Orioles are 1.5-run road favorites on the runline against the Cardinals. The Orioles are +125 to cover, and the Cardinals are -150.

Orioles vs Cardinals Over/Under

• Orioles versus Cardinals, on May 22, has an over/under of 9, with the over being -110 and the under -110.

Bet on Baltimore Orioles vs. St. Louis Cardinals on FanDuel today!

Orioles vs Cardinals Betting Trends

• The Orioles have been favorites in 34 games this season and have come away with the win 21 times (61.8%) in those contests.
• Baltimore has a record of 17-12 when favored by -126 or more this year.
• Contests with the Orioles have gone over the total set by oddsmakers in 23 of 42 chances this season.
• The Orioles are 22-20-0 against the spread in their 42 games with a line set by sportsbooks this season.
• The Cardinals have been the moneyline underdog 22 total times this season. They've finished 9-13 in those games.
• St. Louis has a record of 4-9 when it has played as a moneyline underdog with odds of +108 or longer (30.8%).
• The Cardinals have combined with opponents to go over the total 22 times this season for a 22-23-2 record against the over/under.
• The Cardinals have put together a 22-25-0 record ATS this season.

Orioles Player Leaders

• Gunnar Henderson leads Baltimore in total hits (48) this season while batting .271 with 24 extra-base hits. He has an on-base percentage of .351 and a slugging percentage of .610.
• Among qualifying hitters in the majors, he is 42nd in batting average, 36th in on-base percentage, and fourth in slugging.
• Henderson has recorded a base hit in four straight games. In his last five games he is batting .333 with a triple, four home runs, four walks and seven RBI.
• Adley Rutschman has hit nine homers this season while driving in 28 runs. He's batting .304 this season and slugging .492 with an on-base percentage of .342.
• Among qualified hitters, his batting average places him 16th, his on-base percentage 48th, and his slugging percentage 27th.
• Jordan Westburg is batting .294 with a .519 slugging percentage and 29 RBI this year.
• Westburg heads into this matchup with three games in a row with at least one hit. In his last five games he is batting .263 with a triple, a home run, a walk and two RBI.
• Anthony Santander has been key for Baltimore with 33 hits, an OBP of .283 plus a slugging percentage of .416.

Cardinals Player Leaders

• Brendan Donovan is batting .232 with 11 doubles, a triple, four home runs and 17 walks. He's slugging .370 with an on-base percentage of .311.
• Including all qualifying hitters in the big leagues, he is 107th in batting average, 101st in on-base percentage and 117th in slugging percentage.
• Donovan enters this game on an eight-game hitting streak. In his last 10 games he is batting .262 with three doubles, six walks and two RBI.
• Nolan Arenado paces his team with a .371 slugging percentage. He has a batting average of .270 with an on-base percentage of .325.
• He ranks 44th in batting average, 75th in on-base percentage and 116th in slugging percentage in the majors.
• Lars Nootbaar has seven doubles, five home runs and 22 walks while hitting .213.
• Masyn Winn leads his team with 38 hits and a .345 on-base percentage.

Orioles vs Cardinals Head to Head

• 5/20/2024: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/11/2022: 10-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 5/10/2022: 5-3 BAL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/13/2023: 1-0 STL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 9/12/2023: 5-2 STL (Favorite: Orioles, Spread: -1.5, Total: 11, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/11/2023: 11-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 10, Favorite Moneyline: -172, Underdog Moneyline: +144)

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