Tigers vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 6:11 p.m.

On Monday in MLB, the Detroit Tigers are up against the Washington Nationals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Tigers vs Nationals Game Info

• Detroit Tigers (73-83) vs. Washington Nationals (73-83)
• Date: Monday, September 21, 2026
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and Nationals.TV

Tigers vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-134) | WSH: (+114)
• Spread: DET: -1.5 (+152) | WSH: +1.5 (-184)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Tigers vs Nationals Probable Starting Pitchers

Probable Pitchers: River Ryan (Tigers) - 0-0, 0.00 ERA vs DJ Herz (Nationals) - 0-0, 0.00 ERA

The probable starters are River Ryan for the Tigers and DJ Herz for the Nationals. Ryan did not pitch as the moneyline favorite last season. Herz and his team were underdogs on the moneyline in every game he pitched a season ago.

Tigers vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (58%)

Tigers vs Nationals Moneyline

• Looking at the moneyline for Tigers-Nationals, Detroit is the favorite at -134, and Washington is +114 playing on the road.

Tigers vs Nationals Spread

• The Tigers are 1.5-run home favorites on the runline against the Nationals. The Tigers are +152 to cover, and the Nationals are -184.

Tigers vs Nationals Over/Under

• A combined run total of 8.5 has been set for Tigers-Nationals on Sept. 21, with the over at -110 and the under at -110.

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Tigers vs Nationals Betting Trends

• The Tigers have been favorites in 77 games this season and have come away with the win 42 times (54.5%) in those contests.
• This season Detroit has come away with a win 21 times in 40 chances when named as a favorite of at least -134 on the moneyline.
• The Tigers and their opponents have hit the over in 66 of their 150 games with a total set by oddsmakers this season.
• In 150 games with a line this season, the Tigers have a mark of 77-73-0 against the spread.
• The Nationals have won 49 of the 116 games they were listed as the moneyline underdog this season (42.2%).
• When playing as a moneyline underdog with odds of +114 or longer, Washington has gone 32-49 (39.5%).
• The Nationals have had an over/under set by bookmakers 152 times, and have combined with opponents to go over the total in 80 of those games (80-66-6).
• The Nationals have an 83-69-0 record ATS this season.

Tigers Player Leaders

• Kevin McGonigle leads Detroit OPS (.799) this season. He has a .274 batting average, an on-base percentage of .376, and a slugging percentage of .424.
• Among the qualifying hitters in baseball, his batting average ranks 35th, his on-base percentage ranks 11th, and he is 67th in slugging.
• Riley Greene leads Detroit in total hits (141) this season while batting .285 with 54 extra-base hits. He's slugging .484 with an on-base percentage of .372.
• Among all qualified batters, he is 14th in batting average, 13th in on-base percentage and 24th in slugging percentage.
• Greene heads into this matchup looking to extend his 10-game hit streak. During his last 10 outings he is batting .400 with two doubles, a triple, two home runs, two walks and 10 RBIs.
• Dillon Dingler is batting .243 with a .450 slugging percentage and 89 RBI this year.
• Dingler heads into this game with three games in a row with at least one hit. In his last five games he is hitting .211 with a double and two RBIs.
• Spencer Torkelson has been key for Detroit with 117 hits, an OBP of .326 plus a slugging percentage of .424.

Nationals Player Leaders

• C.J. Abrams has a slugging percentage of .492, a team-high for the Nationals. He's batting .261 with an on-base percentage of .336.
• He ranks 61st in batting average, 61st in on-base percentage and 17th in slugging percentage among all qualified hitters in the big leagues.
• James Wood's 130 hits and .390 on-base percentage both lead his team. He has a batting average of .265 while slugging .513.
• He is 51st in batting average, fourth in on-base percentage and 11th in slugging percentage in MLB.
• Daylen Lile has a .440 slugging percentage, which leads the Nationals.
• Jacob Young is hitting .249 with 21 doubles, three triples, 10 home runs and 33 walks.

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