Orioles vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 5:12 p.m.

In MLB action on Monday, the Baltimore Orioles play the Toronto Blue Jays.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Orioles vs Blue Jays Game Info

• Baltimore Orioles (75-81) vs. Toronto Blue Jays (77-79)
• Date: Monday, September 21, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SNET

Orioles vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-108) | TOR: (-108)
• Spread: BAL: +1.5 (-188) | TOR: -1.5 (+155)
• Total: 7.5 -- Over: (-102) | Under: (-120)

Orioles vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Shane Baz (Orioles) - 6-15, 4.11 ERA vs Trey Yesavage (Blue Jays) - 5-5, 3.65 ERA

The Orioles will give the nod to Shane Baz (6-15) versus the Blue Jays and Trey Yesavage (5-5). Baz and his team are 14-15-0 ATS this season when he starts. Baz's team has been victorious in 45.5% of the games he's started as the moneyline favorite with a record of 5-6. The Blue Jays are 5-12-0 against the spread when Yesavage starts. The Blue Jays have been the underdog on the moneyline in seven of Yesavage's starts this season, and they went 1-6 in those games.

Orioles vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (53.7%)

Orioles vs Blue Jays Moneyline

• Looking at the moneyline for Orioles-Blue Jays, Baltimore is the favorite at -108, and Toronto is -108 playing on the road.

Orioles vs Blue Jays Spread

Orioles vs Blue Jays Over/Under

• An over/under of 7.5 has been set for Orioles-Blue Jays on Sept. 21, with the over being -102 and the under -120.

Bet on Baltimore Orioles vs. Toronto Blue Jays on FanDuel today!

Orioles vs Blue Jays Betting Trends

• The Orioles have been chosen as favorites in 68 games this year and have walked away with the win 36 times (52.9%) in those games.
• Baltimore has a record of 38-34 in contests when bookmakers favor them by -108 or more on the moneyline.
• The Orioles and their opponents have hit the over in 79 of their 155 games with a total set by oddsmakers this season.
• In 155 games with a line this season, the Orioles have a mark of 81-74-0 against the spread.
• The Blue Jays have won 30 of the 69 games they were the underdog on the moneyline this season (43.5%).
• Toronto is 31-39 (winning 44.3% of its games) when it has played as a moneyline underdog of -108 or longer.
• The Blue Jays have played in 152 games with an over/under set, and have combined with opponents to go over the total 80 times (80-70-2).
• The Blue Jays have collected a 74-78-0 record ATS this season.

Orioles Player Leaders

• Pete Alonso has 154 hits and an OBP of .358 to go with a slugging percentage of .500. All three of those stats are best among Baltimore hitters this season. He has a .264 batting average, as well.
• Among all qualified batters in baseball, he ranks 54th in batting average, 32nd in on-base percentage, and 14th in slugging.
• Gunnar Henderson is hitting .223 with 27 doubles, five triples, 23 home runs and 65 walks. He's slugging .397 with an on-base percentage of .308.
• Among all qualifying players, he ranks 119th in batting average, 106th in on-base percentage and 91st in slugging percentage.
• Coby Mayo has collected 90 base hits, an OBP of .298 and a slugging percentage of .471 this season.
• Leody Taveras has been key for Baltimore with 91 hits, an OBP of .286 plus a slugging percentage of .339.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has racked up a team-best .336 on-base percentage. He's batting .263 and slugging .359.
• Including all the qualified players in the big leagues, he ranks 56th in batting average, 61st in on-base percentage and 123rd in slugging percentage.
• Guerrero heads into this game on a four-game hitting streak. During his last five outings he is batting .267 with three walks.
• Kazuma Okamoto's 129 hits pace his team. He has a batting average of .235 while slugging .459 with an on-base percentage of .310.
• He ranks 105th in batting average, 104th in on-base percentage and 37th in slugging percentage in MLB.
• Ernie Clement has put up a slugging percentage of .372, a team-high for the Blue Jays.
• George Springer is batting .248 with 22 doubles, two triples, 15 home runs and 47 walks.

Orioles vs Blue Jays Head to Head

• 9/13/2026: 8-1 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/12/2026: 7-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/11/2026: 7-4 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/7/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/6/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/5/2026: 13-3 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/31/2026: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/30/2026: 6-5 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/29/2026: 6-5 TOR (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/28/2026: 2-1 TOR (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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