Oregon vs James Madison Prediction, Odds, Picks, Best Bets for 2025 CFP First Round

The Saturday schedule in college football includes a matchup between the Oregon Ducks and the James Madison Dukes.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Oregon vs James Madison Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oregon: (-2326) | James Madison: (+1060)
• Spread: Oregon: -21.5 (-105) | James Madison: +21.5 (-115)
• Total: 50.5 -- Over: (-110) | Under: (-110)

Oregon vs James Madison Betting Trends

• Oregon has beaten the spread seven times in 12 games.
• As 21.5-point favorites or more, Oregon is 3-3 against the spread.
• There have been six Oregon games (of 12) that went over the total this season.
• James Madison is 8-5-0 against the spread this season.
• This year, six of James Madison's 13 games have gone over the point total.

Oregon vs James Madison Point Spread

James Madison is the underdog by 21.5 points against Oregon. James Madison is -105 to cover the spread, and Oregon is -115.

Oregon vs James Madison Over/Under

Oregon versus James Madison, on Dec. 20, has an over/under of 50.5, with the over being -110 and the under -110.

Oregon vs James Madison Moneyline

The moneyline numbers for Oregon vs. James Madison reveal Oregon as the favorite (-2326) and James Madison as the underdog (+1060).

Oregon vs. James Madison Points Insights

Oregon vs. James Madison Game Info

• Game day: Saturday, December 20, 2025
• Game time: 7:30 p.m. ET
• TV channel: TNT
• Location: Eugene, Oregon
• Stadium: Autzen Stadium

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Check out even more in-depth Oregon vs. James Madison analysis on FanDuel Research.