Oregon vs James Madison Prediction, Odds, Picks, Best Bets for 2025 CFP First Round

Saturday's slate in college football includes a matchup between the Oregon Ducks and the James Madison Dukes.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Oregon vs James Madison Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oregon: (-2222) | James Madison: (+1100)
• Spread: Oregon: -20.5 (-115) | James Madison: +20.5 (-105)
• Total: 45.5 -- Over: (-115) | Under: (-105)

Oregon vs James Madison Betting Trends

• Oregon is 7-5-0 against the spread this year.
• On the season, Oregon is 3-3 as 20.5-point or better favorites.
• This season, six of Oregon's 12 games have go over the point total.
• James Madison has eight wins in 13 contests against the spread this season.
• James Madison has seen six of its 13 games go over the point total.

Oregon vs James Madison Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Ducks win (87.1%)

Oregon vs James Madison Point Spread

James Madison is an underdog by 20.5 points against Oregon. James Madison is -105 to cover the spread, and Oregon is -115.

Oregon vs James Madison Over/Under

The Oregon-James Madison game on Dec. 20 has been given an over/under of 45.5 points. The over is -115 and the under is -105.

Oregon vs James Madison Moneyline

Oregon is a -2222 favorite on the moneyline, while James Madison is a +1100 underdog.

Oregon vs. James Madison Points Insights

Oregon vs. James Madison Game Info

• Game day: Saturday, December 20, 2025
• Game time: 7:30 p.m. ET
• TV channel: TNT
• Location: Eugene, Oregon
• Stadium: Autzen Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Oregon vs. James Madison analysis on FanDuel Research.