Oklahoma vs Ole Miss Prediction, Odds, Picks, Best Bets for Week 9 2025

NCAA football action on Saturday includes the Oklahoma Sooners taking on the Ole Miss Rebels.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Oklahoma vs Ole Miss Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oklahoma: (-200) | Ole Miss: (+168)
• Spread: Oklahoma: -5.5 (-110) | Ole Miss: +5.5 (-110)
• Total: 52.5 -- Over: (-105) | Under: (-115)

Oklahoma vs Ole Miss Betting Trends

• Oklahoma is 4-3-0 against the spread this season.
• Oklahoma has two wins ATS (2-2) as a 5.5-point or higher favorite in 2025.
• Oklahoma has yet to go over the total this season.
• Ole Miss has four wins in seven contests against the spread this year.
• Ole Miss is winless ATS (0-1) when playing as at least 5.5-point underdogs this year.
• This year, four of Ole Miss' seven games have hit the over.

Oklahoma vs Ole Miss Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Sooners win (64.5%)

Oklahoma vs Ole Miss Point Spread

Ole Miss is a 5.5-point underdog against Oklahoma. Ole Miss is -110 to cover the spread, and Oklahoma is -110.

Oklahoma vs Ole Miss Over/Under

An over/under of 52.5 has been set for Oklahoma-Ole Miss on Oct. 25, with the over being -105 and the under -115.

Oklahoma vs Ole Miss Moneyline

Oklahoma is a -200 favorite on the moneyline, while Ole Miss is a +168 underdog.

Oklahoma vs. Ole Miss Points Insights

Oklahoma vs. Ole Miss Game Info

• Game day: Saturday, October 25, 2025
• Game time: 12 p.m. ET
• TV channel: ABC
• Location: Norman, Oklahoma
• Stadium: Gaylord Family Oklahoma Memorial Stadium

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Check out even more in-depth Oklahoma vs. Ole Miss analysis on FanDuel Research.