Ohio State vs Indiana Prediction, Odds, Picks, Best Bets for Big Ten Championship Game 2025

NCAA football action on Saturday includes the Ohio State Buckeyes facing the Indiana Hoosiers.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Ohio State vs Indiana Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-188) | Indiana: (+158)
• Spread: Ohio State: -4.5 (-105) | Indiana: +4.5 (-115)
• Total: 47.5 -- Over: (-106) | Under: (-114)

Ohio State vs Indiana Betting Trends

• Against the spread, Ohio State is 10-2-0 this year.
• For the year, Ohio State is 9-2 as 4.5-point or better favorites.
• Out of 12 Ohio State games so far this year, four have hit the over.
• Indiana is 7-5-0 against the spread this season.
• Indiana is unbeaten ATS (1-0) as a 4.5-point underdog or greater this season.
• Indiana has played 12 games this season, and eight of them have hit the over.

Ohio State vs Indiana Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (58%)

Ohio State vs Indiana Point Spread

Ohio State is favored by 4.5 points over Indiana. Ohio State is -105 to cover the spread, with Indiana being -115.

Ohio State vs Indiana Over/Under

A combined point total of 47.5 has been set for Ohio State-Indiana on Dec. 6, with the over at -106 and the under at -114.

Ohio State vs Indiana Moneyline

The moneyline numbers for Ohio State vs. Indiana reveal Ohio State as the favorite (-188) and Indiana as the underdog (+158).

Ohio State vs. Indiana Points Insights

Ohio State vs. Indiana Game Info

• Game day: Saturday, December 6, 2025
• Game time: 8 p.m. ET
• TV channel: FOX
• Location: Indianapolis, Indiana
• Stadium: Lucas Oil Stadium

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Check out even more in-depth Ohio State vs. Indiana analysis on FanDuel Research.