Ohio State vs Indiana Prediction, Odds, Picks, Best Bets for Big Ten Championship Game 2025

The Ohio State Buckeyes will take on the Indiana Hoosiers in college football action on Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding today's NCAA football betting odds.

Ohio State vs Indiana Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-190) | Indiana: (+160)
• Spread: Ohio State: -4.5 (-105) | Indiana: +4.5 (-115)
• Total: 47.5 -- Over: (-115) | Under: (-105)

Ohio State vs Indiana Betting Trends

• Against the spread, Ohio State is 10-2-0 this year.
• Against the spread as 4.5-point or better favorites, Ohio State is 9-2.
• Out of 12 Ohio State games so far this year, four have gone over the total.
• Against the spread, Indiana is 7-5-0 this year.
• Indiana has yet to lose ATS (1-0) as a 4.5-point underdog or more this year.
• Of 12 Indiana games so far this season, eight have gone over the total.

Ohio State vs Indiana Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (58%)

Ohio State vs Indiana Point Spread

Ohio State is favored by 4.5 points over Indiana. Ohio State is -105 to cover the spread, with Indiana being -115.

Ohio State vs Indiana Over/Under

Ohio State versus Indiana, on Dec. 6, has an over/under of 47.5, with the over being -115 and the under -105.

Ohio State vs Indiana Moneyline

Indiana is the underdog, +160 on the moneyline, while Ohio State is a -190 favorite.

Ohio State vs. Indiana Points Insights

Ohio State vs. Indiana Game Info

• Game day: Saturday, December 6, 2025
• Game time: 8 p.m. ET
• TV channel: FOX
• Location: Indianapolis, Indiana
• Stadium: Lucas Oil Stadium

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Check out even more in-depth Ohio State vs. Indiana analysis on FanDuel Research.