Ohio State vs Illinois Prediction, Odds, Picks, Best Bets for Week 7 2025

The college football slate on Saturday includes the Ohio State Buckeyes facing the Illinois Fighting Illini.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Ohio State vs Illinois Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-671) | Illinois: (+490)
• Spread: Ohio State: -14.5 (-110) | Illinois: +14.5 (-110)
• Total: 50.5 -- Over: (-114) | Under: (-106)

Ohio State vs Illinois Betting Trends

• Against the spread, Ohio State is 4-1-0 this year.
• Ohio State has won twice ATS (2-1) as a 14.5-point or bigger favorite this year.
• Ohio State has had two games (out of five) hit the over this year.
• Against the spread, Illinois is 5-1-0 this year.
• Illinois has played six games this season, and four of them have hit the over.

Ohio State vs Illinois Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (70.9%)

Ohio State vs Illinois Point Spread

Ohio State is a 14.5-point favorite against Illinois. Ohio State is -110 to cover the spread, and Illinois is -110.

Ohio State vs Illinois Over/Under

An over/under of 50.5 has been set for Ohio State-Illinois on Oct. 11, with the over being -114 and the under -106.

Ohio State vs Illinois Moneyline

Ohio State is a -671 favorite on the moneyline, while Illinois is a +490 underdog.

Ohio State vs. Illinois Points Insights

Ohio State vs. Illinois Game Info

• Game day: Saturday, October 11, 2025
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: Champaign, Illinois
• Stadium: Memorial Stadium (Champaign, IL)

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Check out even more in-depth Ohio State vs. Illinois analysis on FanDuel Research.