Notre Dame vs USC Prediction, Odds, Picks, Best Bets for Week 8 2025

The Notre Dame Fighting Irish are among the college football teams playing on Saturday, versus the USC Trojans.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Notre Dame vs USC Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-370) | USC: (+295)
• Spread: Notre Dame: -10.5 (-105) | USC: +10.5 (-115)
• Total: 59.5 -- Over: (-110) | Under: (-110)

Notre Dame vs USC Betting Trends

• Notre Dame's record against the spread is 3-3-0.
• Notre Dame has two wins ATS (2-1) as a 10.5-point or higher favorite in 2025.
• Notre Dame has played six games this year, and four of them have hit the over.
• Against the spread, USC is 3-3-0 this year.
• USC has seen four of its six games go over the point total.

Notre Dame vs USC Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (78.7%)

Notre Dame vs USC Point Spread

USC is a 10.5-point underdog against Notre Dame. USC is -115 to cover the spread, and Notre Dame is -105.

Notre Dame vs USC Over/Under

The over/under for the Notre Dame versus USC matchup on Oct. 18 has been set at 59.5, with -110 odds on the over and -110 odds on the under.

Notre Dame vs USC Moneyline

Looking at the moneyline for USC-Notre Dame, USC is the underdog at +295, and Notre Dame is -370.

Notre Dame vs. USC Points Insights

Notre Dame vs. USC Game Info

• Game day: Saturday, October 18, 2025
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: South Bend, Indiana
• Stadium: Notre Dame Stadium

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Check out even more in-depth Notre Dame vs. USC analysis on FanDuel Research.