Northwestern vs Purdue Prediction, Odds, Picks, Best Bets for Week 8 2025

Saturday's slate in college football includes a matchup between the Northwestern Wildcats and the Purdue Boilermakers.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Northwestern vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Northwestern: (-154) | Purdue: (+130)
• Spread: Northwestern: -3.5 (100) | Purdue: +3.5 (-122)
• Total: 46.5 -- Over: (-105) | Under: (-115)

Northwestern vs Purdue Betting Trends

• Northwestern has four wins in six games against the spread this year.
• Northwestern has two wins ATS (2-1) as a 3.5-point or higher favorite in 2025.
• Northwestern has had one game (of six) hit the over this year.
• Purdue is 3-3-0 against the spread this year.
• As a 3.5-point underdog or more, Purdue has two wins ATS (2-2).
• Two Purdue games (of six) have hit the over this year.

Northwestern vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Wildcats win (67.6%)

Northwestern vs Purdue Point Spread

Northwestern is favored by 3.5 points against Purdue. Northwestern is +100 to cover the spread, while Purdue is -122.

Northwestern vs Purdue Over/Under

The Northwestern-Purdue game on Oct. 18 has been given an over/under of 46.5 points. The over is -105 and the under is -115.

Northwestern vs Purdue Moneyline

Looking at the moneyline for Purdue-Northwestern, Purdue is the underdog at +130, and Northwestern is -154.

Northwestern vs. Purdue Points Insights

Northwestern vs. Purdue Game Info

• Game day: Saturday, October 18, 2025
• Game time: 3 p.m. ET
• TV channel: BTN
• Location: Evanston, Illinois
• Stadium: Northwestern Medicine Field at Martin Stadium

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Check out even more in-depth Northwestern vs. Purdue analysis on FanDuel Research.