NFL Games This Sunday: Predictions, Odds, Picks, Best Bets for Week 7

The Week 7 NFL slate for Sunday should have plenty of excitement on the field. Among those games is the San Francisco 49ers squaring off against the Atlanta Falcons.

Here is what you need to know in terms of the betting odds for Sunday.

Saints vs. Steelers

Against the New Orleans Saints (2-4), who sport the 30th-ranked run defense this season, Jaylen Warren and the Pittsburgh Steelers (4-2) should have success running the ball when the two teams square off on Sunday, Oct. 25 at 9:30 a.m. ET. Warren has been one of the NFL's top runners this year, ranking seventh-best in the league in rushing yards.

• Game Preview: Pittsburgh Steelers vs. New Orleans Saints
• Projected Favorite: Steelers (70.43% win probability)
• Spread: Pittsburgh (-3)
• Total: 44.5 -- Over: (-112) | Under: (-108)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on New Orleans vs. Pittsburgh with FanDuel Sportsbook.

Ravens vs. Bengals

One of the best running backs in football will be featured when Derrick Henry and the Baltimore Ravens (4-2) host the Cincinnati Bengals (3-2) on Sunday, October 25, 2026.

• Game Preview: Cincinnati Bengals at Baltimore Ravens
• Projected Favorite: Ravens (61.21% win probability)
• Spread: Cincinnati (-1.5)
• Total: 48.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. Cincinnati with FanDuel Sportsbook.

Titans vs. Browns

Don't bet on a bunch of scoring when the Cleveland Browns (4-2) visit the Tennessee Titans (1-5) at 1 p.m. ET on Oct. 25, as both teams have scoring offenses that rank bottom-five in the league. The Browns are 28th (17.7 points per game), while the Titans are 31st (17.7 points per game).

• Game Preview: Cleveland Browns at Tennessee Titans
• Projected Favorite: Browns (60.76% win probability)
• Spread: Cleveland (-1.5)
• Total: 37.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tennessee vs. Cleveland with FanDuel Sportsbook.

Falcons vs. 49ers

The San Francisco 49ers (6-0) are scheduled to collide with the Atlanta Falcons (2-4) at Mercedes-Benz Stadium on Sunday, Oct. 25 at 1 p.m. ET. In their previous contests, the 49ers took down the Commanders 23-17, and the Falcons lost 31-23 to the Bears.

• Game Preview: San Francisco 49ers at Atlanta Falcons
• Projected Favorite: 49ers (53.66% win probability)
• Spread: San Francisco (-2.5)
• Total: 49.5 -- Over: (-114) | Under: (-106)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Atlanta vs. San Francisco with FanDuel Sportsbook.

Panthers vs. Buccaneers

The 1 p.m. ET contest on Oct. 25 between the Carolina Panthers (3-2) and the Tampa Bay Buccaneers (1-5) should be a competitive matchup, as Chuba Hubbard has been one of the league's top rushers this year, and the Buccaneers have a top-five run defense, ranking second-best in the NFL at 75.5 rushing yards surrendered per contest.

• Game Preview: Tampa Bay Buccaneers at Carolina Panthers
• Projected Favorite: Panthers (69.35% win probability)
• Spread: Carolina (-3)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Tampa Bay with FanDuel Sportsbook.

Vikings vs. Colts

Jonathan Taylor, who ranks sixth-best in the NFL in rushing yards, will attempt to lead the way for the Indianapolis Colts (2-4) on Oct. 25 at 1 p.m. ET, when they visit the Minnesota Vikings (5-0) and their fifth-best run defense (86.6 rushing yards allowed per game).

• Game Preview: Indianapolis Colts at Minnesota Vikings
• Projected Favorite: Vikings (70.83% win probability)
• Spread: Minnesota (-6.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Minnesota vs. Indianapolis with FanDuel Sportsbook.

Jets vs. Dolphins

When the New York Jets (2-4) and the Miami Dolphins (0-5) match up on Sunday, Oct. 25 at 1 p.m. ET, they will both be aiming to rebound after losing their last game. The Jets lost 26-19 to the Patriots, and the Dolphins are coming off a 31-24 loss to the Bengals.

• Game Preview: Miami Dolphins at New York Jets
• Projected Favorite: Jets (63.76% win probability)
• Spread: New York (-4.5)
• Total: 39.5 -- Over: (-106) | Under: (-114)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Miami with FanDuel Sportsbook.

Texans vs. Giants

C.J. Stroud and the Houston Texans (2-4) will get a stiff test when they go toe to toe with the New York Giants (3-2-1), who own the league's fifth-best pass D, on Sunday, Oct. 25 at 1 p.m. ET. Stroud ranks second-best in the NFL in passing yards.

• Game Preview: New York Giants at Houston Texans
• Projected Favorite: Texans (68.23% win probability)
• Spread: Houston (-10.5)
• Total: 43.5 -- Over: (-102) | Under: (-120)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Houston vs. New York with FanDuel Sportsbook.

Cardinals vs. Broncos

The Denver Broncos (4-2) are slated to do battle against the Arizona Cardinals (2-4) at State Farm Stadium on Sunday, Oct. 25 at 4:05 p.m. ET. Both squads won their previous game, as the Broncos took down the Seahawks 17-14, and the Cardinals won 18-16 against the Rams.

• Game Preview: Denver Broncos at Arizona Cardinals
• Projected Favorite: Broncos (62.87% win probability)
• Spread: Denver (-4.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Arizona vs. Denver with FanDuel Sportsbook.

Raiders vs. Rams

Kirk Cousins and the Las Vegas Raiders (3-3) will get a challenge when they collide with the Los Angeles Rams (2-4), who sport the NFL's second-best pass D, on Sunday, Oct. 25 at 4:25 p.m. ET. Cousins ranks fifth-best in the league in passing yards.

• Game Preview: Los Angeles Rams at Las Vegas Raiders
• Projected Favorite: Rams (63.55% win probability)
• Spread: Los Angeles (-4.5)
• Total: 48.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Las Vegas vs. Los Angeles with FanDuel Sportsbook.

Lions vs. Packers

The Detroit Lions (3-2) host the Green Bay Packers (4-2) on Sunday at 4:25 p.m. ET, in a battle featuring a pair of the best offensive players in football in quarterback Jared Goff and pass-catcher Christian Watson.

• Game Preview: Green Bay Packers at Detroit Lions
• Projected Favorite: Lions (69.95% win probability)
• Spread: Detroit (-3)
• Total: 52.5 -- Over: (-120) | Under: (-102)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Detroit vs. Green Bay with FanDuel Sportsbook.

Seahawks vs. Chiefs

The Seattle Seahawks (3-3) are slated to collide with the Kansas City Chiefs (5-0) at Lumen Field on Sunday, Oct. 25 at 8:20 p.m. ET. In their last contests, the Seahawks were taken down by the Broncos 17-14, and the Chiefs won 22-6 against the Chargers.

• Game Preview: Kansas City Chiefs at Seattle Seahawks
• Projected Favorite: Chiefs (56.39% win probability)
• Spread: Seattle (-2.5)
• Total: 42.5 -- Over: (-112) | Under: (-108)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Seattle vs. Kansas City with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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