Nebraska vs Michigan State Prediction, Odds, Picks, Best Bets for Week 4 2026

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In college football action on Saturday, the Nebraska Cornhuskers take on the Michigan State Spartans.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Nebraska vs Michigan State Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Nebraska: (-230) | Michigan State: (+188)
Spread: Nebraska: -5.5 (-120) | Michigan State: +5.5 (-102)
Total: 48.5 -- Over: (-110) | Under: (-110)

Nebraska has posted two wins against the spread this year.
Nebraska has two wins ATS (2-1) as a 5.5-point or higher favorite in 2026.
Nebraska has had two games (out of three) go over the total this year.
Michigan State has posted two wins against the spread this season.
Michigan State has yet to lose ATS (1-0) as a 5.5-point underdog or more this year.
One Michigan State game (out of three) has gone over the point total this season.

All college football win probability predictions and picks are according to numberFire.
Prediction: Cornhuskers win (71.8%)

Nebraska is favored by 5.5 points versus Michigan State. Nebraska is -120 to cover the spread, while Michigan State is -102.

The Nebraska-Michigan State matchup on Sept. 26 has been given an over/under of 48.5 points. The over is -110 and the under is -110.

Looking at the moneyline for Nebraska-Michigan State, Nebraska is the favorite at -230, and Michigan State is +188.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Nebraska	46.3	13	11.7	15	50.5	3
Michigan State	25.0	102	18.0	46	50.2	3

Check out even more in-depth Nebraska vs. Michigan State analysis on FanDuel Research.

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