Nebraska vs Michigan State Prediction, Odds, Picks, Best Bets for Week 4 2026

Saturday's slate in college football includes a matchup between the Nebraska Cornhuskers and the Michigan State Spartans.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Nebraska vs Michigan State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Nebraska: (-230) | Michigan State: (+188)
• Spread: Nebraska: -5.5 (-120) | Michigan State: +5.5 (-102)
• Total: 48.5 -- Over: (-110) | Under: (-110)

Nebraska vs Michigan State Betting Trends

• Nebraska has posted two wins against the spread this year.
• As at least a 5.5-point favorite, Nebraska has two wins ATS (2-1).
• Nebraska has had two games (out of three) hit the over this year.
• Michigan State owns two wins against the spread this season.
• Michigan State has covered every time (1-0) as a 5.5-point or greater underdog this year.
• One of Michigan State's three games has hit the over.

Nebraska vs Michigan State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cornhuskers win (75.2%)

Nebraska vs Michigan State Point Spread

Nebraska is favored by 5.5 points over Michigan State. Nebraska is -120 to cover the spread, with Michigan State being -102.

Nebraska vs Michigan State Over/Under

Nebraska versus Michigan State on Sept. 26 has an over/under of 48.5 points, with the over -110 and the under -110.

Nebraska vs Michigan State Moneyline

Looking at the moneyline for Nebraska-Michigan State, Nebraska is the favorite at -230, and Michigan State is +188.

Nebraska vs. Michigan State Points Insights

Nebraska vs. Michigan State Game Info

• Game day: Saturday, September 26, 2026
• Game time: 5 p.m. ET
• TV channel: BTN
• Location: East Lansing, Michigan
• Stadium: Spartan Stadium

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Check out even more in-depth Nebraska vs. Michigan State analysis on FanDuel Research.