Nationals vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 7:12 p.m.

Saturday's slate in the MLB includes a matchup between the Washington Nationals and the St. Louis Cardinals.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Nationals vs Cardinals Game Info

• Washington Nationals (72-82) vs. St. Louis Cardinals (75-79)
• Date: Saturday, September 19, 2026
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Nationals.TV

Nationals vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-110) | STL: (-106)
• Spread: WSH: -1.5 (+158) | STL: +1.5 (-192)
• Total: 7.5 -- Over: (-114) | Under: (-106)

Nationals vs Cardinals Probable Starting Pitchers

Probable Pitchers: Andrew Alvarez (Nationals) - 2-6, 3.35 ERA vs Michael McGreevy (Cardinals) - 7-9, 3.83 ERA

This contest's pitching matchup is set, as the Nationals will send Andrew Alvarez (2-6) to the mound, while Michael McGreevy (7-9) will get the nod for the Cardinals. When Alvarez starts, his team is 5-10-0 against the spread this season. Alvarez's team has won 50% of his starts when they are favored on the moneyline (3-3). The Cardinals have a 17-12-0 record against the spread in McGreevy's starts. The Cardinals are 11-10 in McGreevy's 21 starts this season that they were the moneyline underdog.

Nationals vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (55%)

Nationals vs Cardinals Moneyline

• Washington is the favorite, -110 on the moneyline, while St. Louis is a -106 underdog despite being at home.

Nationals vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Nationals. The Cardinals are -192 to cover, and the Nationals are +158.

Nationals vs Cardinals Over/Under

• The Nationals-Cardinals contest on Sept. 19 has been given an over/under of 7.5 runs. The over is set at -114 and the under at -106.

Bet on Washington Nationals vs. St. Louis Cardinals on FanDuel today!

Nationals vs Cardinals Betting Trends

• The Nationals have won in 18, or 56.2%, of the 32 contests they have been named as odds-on favorites in this year.
• This year Washington has won 18 of 32 games when listed as at least -110 on the moneyline.
• Contests with the Nationals have gone over the total set by bookmakers in 79 of 150 chances this season.
• The Nationals are 82-68-0 against the spread in their 150 games that had a posted line this season.
• The Cardinals have gone 45-52 in games they were listed as the moneyline underdog (winning 46.4% of those games).
• When playing as a moneyline underdog with odds of -106 or longer, St. Louis has a record of 45-50 (47.4%).
• The Cardinals have combined with opponents to hit the over on the total 70 times this season for a 70-73-7 record against the over/under.
• The Cardinals have collected an 80-70-0 record ATS this season (covering 53.3% of the time).

Nationals Player Leaders

• C.J. Abrams has an OPS of .831, fueled by an OBP of .338 and a team-best slugging percentage of .493 this season. He has a .264 batting average.
• He ranks 55th in batting average, 57th in on-base percentage, and 18th in slugging among all qualified hitters in MLB.
• Abrams will look for his sixth straight game with a hit in this contest. During his last five outings he is hitting .381 with four doubles and two RBIs.
• James Wood has 128 hits and an OBP of .392, both of which lead the Nationals this season. He's batting .266 and slugging .519.
• Among qualifying batters, his batting average ranks him 52nd, his on-base percentage third, and his slugging percentage ninth.
• Daylen Lile is batting .250 with a .435 slugging percentage and 86 RBI this year.
• Jacob Young has 10 home runs, 47 RBI and a batting average of .248 this season.

Cardinals Player Leaders

• Alec Burleson has a .469 slugging percentage, which leads the Cardinals. He's batting .283 with an on-base percentage of .349.
• He ranks 18th in batting average, 43rd in on-base percentage and 32nd in slugging percentage among all qualifying hitters in MLB.
• Jordan Walker's 161 hits pace his team. He has a batting average of .279 while slugging .481 with an on-base percentage of .336.
• Including all qualified hitters, he is 24th in batting average, 60th in on-base percentage and 27th in slugging percentage.
• Ivan Herrera has racked up an on-base percentage of .355, a team-best for the Cardinals.
• JJ Wetherholt is hitting .240 with 14 doubles, 17 home runs and 63 walks.

Nationals vs Cardinals Head to Head

• 9/18/2026: 9-1 WSH (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/8/2026: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/7/2026: 7-6 STL (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2026: 9-6 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2025: 8-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/9/2025: 8-2 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/11/2025: 6-1 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/10/2025: 4-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/9/2025: 10-0 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/28/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

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