Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 6:11 p.m.

The Chicago Cubs will take on the Cincinnati Reds in MLB action on Saturday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Cubs vs Reds Game Info

• Chicago Cubs (85-69) vs. Cincinnati Reds (72-82)
• Date: Saturday, September 19, 2026
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-146) | CIN: (+124)
• Spread: CHC: -1.5 (+110) | CIN: +1.5 (-132)
• Total: 9.5 -- Over: (+104) | Under: (-128)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 8-5, 4.16 ERA vs Nick Lodolo (Reds) - 3-5, 5.12 ERA

The probable pitchers are Matthew Boyd (8-5) for the Cubs and Nick Lodolo (3-5) for the Reds. When Boyd starts, his team is 9-10-0 against the spread this season. When Boyd starts a game and his team is the favorite on the moneyline, they have a record of 8-5. The Reds have gone 8-11-0 ATS in Lodolo's 19 starts with a set spread. The Reds have been the moneyline underdog in 14 of Lodolo's starts this season, and they went 6-8 in those matchups.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (63.4%)

Cubs vs Reds Moneyline

• Cincinnati is a +124 underdog on the moneyline, while Chicago is a -146 favorite on the road.

Cubs vs Reds Spread

• The Cubs are at the Reds and are favored by 1.5 runs on the spread. The Cubs are +110 to cover the runline, with the Reds being -132.

Cubs vs Reds Over/Under

• The over/under for Cubs-Reds on Sept. 19 is 9.5. The over is +104, and the under is -128.

Bet on Chicago Cubs vs. Cincinnati Reds on FanDuel today!

Cubs vs Reds Betting Trends

• The Cubs have won in 57, or 56.4%, of the 101 contests they have been named as odds-on favorites in this year.
• Chicago has a record of 30-19 in contests when bookmakers favor them by -146 or more on the moneyline.
• Contests with the Cubs have gone over the total set by sportsbooks in 85 of 149 chances this season.
• In 149 games with a line this season, the Cubs have a mark of 71-78-0 against the spread.
• The Reds have won 50 of the 106 games they were the underdog on the moneyline this season (47.2%).
• In games it has played as a moneyline underdog with odds of +124 or longer, Cincinnati has a 16-28 record (winning only 36.4% of its games).
• The Reds have had an over/under set by oddsmakers 150 times, and have combined with opponents to go over the total in 80 of those games (80-68-2).
• The Reds have collected a 77-73-0 record ATS this season.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in OBP (.372), slugging percentage (.576) and total hits (167) this season. He has a .280 batting average.
• Among qualifying batters in MLB, his batting average ranks 23rd, his on-base percentage ranks 14th, and he is second in slugging.
• Alex Bregman is batting .262 with 32 doubles, two triples, 26 home runs and 73 walks, while slugging .454 with an on-base percentage of .351.
• Among qualifiers, he is 60th in batting average, 40th in on-base percentage and 41st in slugging percentage.
• Seiya Suzuki is batting .265 with a .466 slugging percentage and 83 RBI this year.
• Nico Hoerner has been key for Chicago with 158 hits, an OBP of .315 plus a slugging percentage of .353.

Reds Player Leaders

• Sal Stewart has put up a team-high .476 slugging percentage. He's batting .271 with an on-base percentage of .338.
• Including all qualified hitters in MLB, he is 42nd in batting average, 57th in on-base percentage and 30th in slugging percentage.
• Stewart hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .316 with a home run and three RBIs.
• Elly De La Cruz has racked up 152 hits with a .366 OBP to pace his team in both. He has a batting average of .287 while slugging .519.
• Including all qualifying hitters, he ranks 13th in batting average, 20th in on-base percentage and ninth in slugging percentage.
• JJ Bleday is hitting .214 with 16 doubles, two triples, 22 home runs and 70 walks.
• Eugenio Suarez has 17 doubles, 24 home runs and 51 walks while batting .211.

Cubs vs Reds Head to Head

• 9/18/2026: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/30/2026: 7-5 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +142)
• 8/29/2026: 17-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -205, Underdog Moneyline: +190)
• 8/28/2026: 10-8 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +176)
• 7/12/2026: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/11/2026: 5-3 CHC (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2026: 4-0 CIN (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/7/2026: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/6/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/5/2026: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!