Michigan vs La Salle College Basketball Prediction, Odds, Picks, Best Bets for Dec. 21

The Michigan Wolverines (10-0) will attempt to continue a 10-game winning streak when they host the La Salle Explorers (4-8) on December 21, 2025 at Crisler Center.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Michigan vs. La Salle Game Info and Odds

• Game day: Sunday, December 21, 2025
• Game time: 4 p.m. ET
• TV channel: Peacock
• Location: Ann Arbor, Michigan
• Arena: Crisler Center

Michigan vs. La Salle Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Michigan win (98.5%)

Michigan is a 40.5-point favorite against La Salle on Sunday and the over/under has been set at 155.5 points. Here are some betting insights and trends to help you make an informed wager on the matchup.

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Michigan vs. La Salle: ATS Betting Stats and Trends

• Michigan has won six games against the spread this season, while failing to cover four times.
• La Salle has covered five times in 11 chances against the spread this season.
• Against the spread last year, the Wolverines performed worse at home, covering five times in 15 home games, and five times in 10 road games.
• Against the spread, the Explorers have performed better at home (2-1-0) than away (2-2-0).

Michigan vs. La Salle Head-to-Head Comparison

• Michigan is outscoring opponents by 27 points per game with a +270 scoring differential overall. It puts up 94.7 points per game (third in college basketball) and gives up 67.7 per contest (64th in college basketball).
• Yaxel Lendeborg ranks 171st in the country with a team-high 16.4 points per game.
• La Salle is being outscored by 1.3 points per game, with a -16 scoring differential overall. It puts up 67.7 points per game (337th in college basketball), and gives up 69 per contest (88th in college basketball).
• Jaeden Marshall paces La Salle, scoring 12.6 points per game (598th in college basketball).
• The Wolverines win the rebound battle by 13.2 boards on average. They collect 41.6 rebounds per game, which ranks second in college basketball, while their opponents pull down 28.4 per contest.
• Aday Mara's 8.3 rebounds per game lead the Wolverines and rank 61st in college basketball play.
• The Explorers average 33.2 rebounds per game (187th in college basketball) while allowing 27.8 per outing to opponents. They outrebound opponents by 5.4 boards per game.
• Josiah Harris is 374th in the nation with 5.7 rebounds per game, leading the Explorers.
• Michigan puts up 110.7 points per 100 possessions (12th in college basketball), while allowing 79.1 points per 100 possessions (ninth in college basketball).
• The Explorers average 89.1 points per 100 possessions on offense (325th in college basketball), and give up 90.8 points per 100 possessions (158th in college basketball).

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