Miami (FL) vs Louisville Prediction, Odds, Picks, Best Bets for Week 8 2025

Friday's slate in college football includes a matchup between the Miami Hurricanes and the Louisville Cardinals.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info about today's NCAA football betting odds.

Miami (FL) vs Louisville Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Miami (FL): (-500) | Louisville: (+385)
• Spread: Miami (FL): -13.5 (-105) | Louisville: +13.5 (-115)
• Total: 49.5 -- Over: (-110) | Under: (-110)

Miami (FL) vs Louisville Betting Trends

• Miami (FL) has covered the spread four times in five games.
• Miami (FL) owns one win ATS (1-1) as a 13.5-point favorite or greater this season.
• Miami (FL) has had two games (out of five) go over the total this season.
• Louisville has one win against the spread this year.
• There have been three Louisville games (out of five) that went over the total this year.

Miami (FL) vs Louisville Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hurricanes win (86.2%)

Miami (FL) vs Louisville Point Spread

Louisville is a 13.5-point underdog against Miami (FL). Louisville is -115 to cover the spread, and Miami (FL) is -105.

Miami (FL) vs Louisville Over/Under

The over/under for Miami (FL)-Louisville on Oct. 17 is 49.5. The over is -110, and the under is -110.

Miami (FL) vs Louisville Moneyline

Miami (FL) is a -500 favorite on the moneyline, while Louisville is a +385 underdog.

Miami (FL) vs. Louisville Points Insights

Miami (FL) vs. Louisville Game Info

• Game day: Friday, October 17, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Miami Gardens, Florida
• Stadium: Hard Rock Stadium

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Check out even more in-depth Miami (FL) vs. Louisville analysis on FanDuel Research.