Matthew Stafford Fantasy Football Week 5: Stats and Projections vs. 49ers

Los Angeles Rams quarterback Matthew Stafford will match up with the sixth-ranked pass defense of the San Francisco 49ers (165 yards allowed per game) in Week 5, at 8:15 p.m. ET on Thursday.

Is Stafford a daily fantasy option for you this week, as he plays the 49ers? More stats and info can be found below, so take a look.

Thinking about playing Stafford this week? Start building your FanDuel fantasy football lineup today!

Matthew Stafford Week 5 Fantasy Football Projection

• Matchup: Los Angeles Rams vs. San Francisco 49ers
• Game Date: October 2, 2025
• Game Time: 8:15 p.m.
• Projected Fantasy Points: 15.3
• Projected Passing Yards: 239.21
• Projected Passing TDs: 1.62
• Projected Rushing Yards: 5.31
• Projected Rushing TDs: 0.06

Projections provided by numberFire

Stafford Fantasy Performance

• Among players at the QB position, Stafford is currently the 12th-ranked player in fantasy (14th overall), with 72.1 total fantasy points (18 per game).
• During his last three games, Stafford has compiled 869 passing yards (71-of-107) for seven passing TDs with two picks, leading to 58.5 fantasy points (19.5 per game) during that period. On the ground, he's contributed -2 yards rushing on six carries.
• The high point of Stafford's season as a fantasy producer came against the Indianapolis Colts last week, as he posted 27.4 fantasy points by rushing for four yards on four attempts.
• From a fantasy perspective, Matthew Stafford's game against the Houston Texans in Week 1 was his worst of the year, as he posted 13.6 fantasy points. He passed for 245 yards and one touchdown, and threw zero picks on the day.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

49ers Defensive Performance

• San Francisco has not let a player record over 300 yards passing versus them in a matchup yet this season.
• A total of Three players have thrown for at least one TD versus the 49ers this season.
• San Francisco has given up two or more TD passes to one opposing QB this season.
• The 49ers have allowed one player to pass for three or more TDs in a game this season.
• San Francisco has allowed one player to pick up more than 100 yards receiving in a game this year.
• A total of Five players have hauled in a touchdown pass versus the 49ers this season.
• No player has hauled in more than one touchdown pass versus San Francisco this year.
• One player has recorded more than 100 yards rushing in a game versus the 49ers this year.
• San Francisco has given up at least one rushing touchdown to two players this season.
• The 49ers have not given up two or more rushing TDs to an opposing player this season.

Want more data and analysis on Matthew Stafford? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.