Matthew Stafford Fantasy Football Week 1: Stats and Projections vs. 49ers

Los Angeles Rams quarterback Matthew Stafford will take on the team with last year's 25th-ranked pass defense, the San Francisco 49ers (232.4 yards allowed per game), in Week 1 -- beginning at 8:35 p.m. ET on Thursday.

For more info on Stafford, if you're considering him for your DFS lineup, check out this article before his upcoming game versus the 49ers.

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Matthew Stafford Week 1 Fantasy Football Projection

• Matchup: Los Angeles Rams vs. San Francisco 49ers
• Game Date: September 10, 2026
• Game Time: 8:35 p.m.
• Projected Fantasy Points: 17.3
• Projected Passing Yards: 271.56
• Projected Passing TDs: 1.89
• Projected Rushing Yards: 3.72
• Projected Rushing TDs: 0.03

Projections provided by numberFire

Stafford 2025 Fantasy Performance

• In his best game last season -- Week 16 versus the Seattle Seahawks -- Stafford accumulated 30.9 fantasy points. His stat line: 29-of-49 (59.2%), 457 yards, 3 TDs, 0 INTs.
• Stafford recorded 28.6 fantasy points (22-of-35 (62.9%), 374 yards, 3 TDs, 0 INTs) in Week 3 versus the Seattle Seahawks, his second-best game last season.
• In his worst game of the year -- Week 6 versus the Baltimore Ravens -- Stafford finished with 9.3 fantasy points. His stat line was: 17-of-26 (65.4%), 181 yards, 1 TD, 0 INTs.
• In his second-worst game of the season (Week 2 versus the Chicago Bears), Stafford finished with 10.2 fantasy points -- 20-of-42 (47.6%), 258 yards, 0 TDs, 0 INTs.

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49ers Defensive Performance

• Against San Francisco last year, four players recorded more than 300 passing yards in a game.
• Last season, the 49ers allowed 15 QBs to throw at least one TD pass in a game.
• Against San Francisco last season, 10 players threw for at least two touchdowns in a game.
• Last season, the 49ers allowed only three players to throw for at least three TDs in a game.
• Through the air, San Francisco gave up more than 100 receiving yards to four players last season.
• The 49ers allowed 27 players to haul in a TD pass against them last season.
• Looking at pass defense, San Francisco allowed only two players to catch at least two touchdown passes against it last year.
• In terms of run D, the 49ers allowed only two players to pile up more than 100 rushing yards in a game last season.
• Against San Francisco last season, 11 players rushed for at least one TD.
• Only two players ran for multiple scores in a game against the 49ers last year.

Want more data and analysis on Matthew Stafford? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.