LSU vs South Carolina Prediction, Odds, Picks, Best Bets for Week 7 2025

The Saturday schedule in college football includes a matchup between the LSU Tigers and the South Carolina Gamecocks.

We've got you covered, in terms of the vital info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

LSU vs South Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LSU: (-340) | South Carolina: (+275)
• Spread: LSU: -8.5 (-115) | South Carolina: +8.5 (-105)
• Total: 44.5 -- Over: (-110) | Under: (-110)

LSU vs South Carolina Betting Trends

• LSU has won twice against the spread this season.
• LSU is winless ATS (0-2) as an 8.5-point favorite or greater this season.
• LSU has had one game (of five) go over the total this season.
• South Carolina has covered the spread three times in five games.
• South Carolina has covered every time (1-0) as an 8.5-point or greater underdog this year.
• South Carolina has played two games (out of five) which finished over the total this year.

LSU vs South Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (53.1%)

LSU vs South Carolina Point Spread

LSU is favored by 8.5 points over South Carolina. LSU is -115 to cover the spread, with South Carolina being -105.

LSU vs South Carolina Over/Under

A total of 44.5 points has been set for the LSU-South Carolina matchup on Oct. 11, with the over available at -110 and the under at -110.

LSU vs South Carolina Moneyline

Looking at the moneyline for LSU-South Carolina, LSU is the favorite at -340, and South Carolina is +275.

LSU vs. South Carolina Points Insights

LSU vs. South Carolina Game Info

• Game day: Saturday, October 11, 2025
• Game time: 7:45 p.m. ET
• TV channel: SEC Network
• Location: Baton Rouge, Louisiana
• Stadium: Tiger Stadium

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