Louisville vs Virginia Prediction, Odds, Picks, Best Bets for Week 6 2025

The Louisville Cardinals versus the Virginia Cavaliers is on the college football schedule for Saturday.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Louisville vs Virginia Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-240) | Virginia: (+195)
• Spread: Louisville: -6.5 (-115) | Virginia: +6.5 (-105)
• Total: 62.5 -- Over: (-102) | Under: (-120)

Louisville vs Virginia Betting Trends

• Louisville has one win against the spread this season.
• Louisville has no wins ATS (0-3) as a 6.5-point favorite or greater this year.
• There have been three Louisville games (of four) that went over the total this season.
• Virginia has four wins in five contests against the spread this year.
• Virginia has covered every time (1-0) as a 6.5-point or greater underdog this season.
• All five Virginia games have hit the over this year.

Louisville vs Virginia Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (80%)

Louisville vs Virginia Point Spread

Virginia is the underdog by 6.5 points against Louisville. Virginia is -115 to cover the spread, and Louisville is -105.

Louisville vs Virginia Over/Under

The over/under for the Louisville versus Virginia game on Oct. 4 has been set at 62.5, with -102 odds on the over and -120 odds on the under.

Louisville vs Virginia Moneyline

Virginia is the underdog, +195 on the moneyline, while Louisville is a -240 favorite.

Louisville vs. Virginia Points Insights

Louisville vs. Virginia Game Info

• Game day: Saturday, October 4, 2025
• Game time: 3:30 p.m. ET
• TV channel: ESPN2
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

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Check out even more in-depth Louisville vs. Virginia analysis on FanDuel Research.