Louisville vs Virginia Prediction, Odds, Picks, Best Bets for Week 6 2025

The Louisville Cardinals versus the Virginia Cavaliers is on the college football schedule for Saturday.

We've got you covered, in terms of the most important info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Louisville vs Virginia Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-245) | Virginia: (+198)
• Spread: Louisville: -6.5 (-118) | Virginia: +6.5 (-104)
• Total: 59.5 -- Over: (-115) | Under: (-105)

Louisville vs Virginia Betting Trends

• Louisville hasn won once against the spread this season.
• Louisville has yet to win ATS (0-3) when playing as at least 6.5-point favorites this year.
• This season, three of Louisville's four games have hit the over.
• Against the spread, Virginia is 4-1-0 this season.
• Virginia is unbeaten ATS (1-0) as a 6.5-point underdog or more this year.
• Every Virginia game has hit the over this season.

Louisville vs Virginia Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (80%)

Louisville vs Virginia Point Spread

Louisville is a 6.5-point favorite against Virginia. Louisville is -118 to cover the spread, and Virginia is -104.

Louisville vs Virginia Over/Under

The over/under for Louisville-Virginia on Oct. 4 is 59.5. The over is -115, and the under is -105.

Louisville vs Virginia Moneyline

Looking at the moneyline for Virginia-Louisville, Virginia is the underdog at +198, and Louisville is -245.

Louisville vs. Virginia Points Insights

Louisville vs. Virginia Game Info

• Game day: Saturday, October 4, 2025
• Game time: 3:30 p.m. ET
• TV channel: ESPN2
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

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Check out even more in-depth Louisville vs. Virginia analysis on FanDuel Research.