Louisville vs Toledo Prediction, Odds, Picks, Best Bets for Boca Raton Bowl 2025

The Louisville Cardinals are among the college football teams in action on Tuesday, versus the Toledo Rockets.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Louisville vs Toledo Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-334) | Toledo: (+270)
• Spread: Louisville: -8.5 (-115) | Toledo: +8.5 (-105)
• Total: 43.5 -- Over: (-115) | Under: (-105)

Louisville vs Toledo Betting Trends

• Louisville has four wins in 12 games against the spread this year.
• Louisville has won once ATS (1-5) as an 8.5-point or higher favorite this year.
• Out of 12 Louisville games so far this year, five have gone over the total.
• Toledo has nine wins in 12 contests against the spread this year.
• Toledo is unbeaten ATS (1-0) as an 8.5-point underdog or greater this year.
• Toledo has seen six of its 12 games go over the point total.

Louisville vs Toledo Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (55.8%)

Louisville vs Toledo Point Spread

Toledo is a 8.5-point underdog against Louisville. Toledo is -105 to cover the spread, and Louisville is -115.

Louisville vs Toledo Over/Under

The over/under for Louisville-Toledo on Dec. 23 is 43.5. The over is -115, and the under is -105.

Louisville vs Toledo Moneyline

The Louisville vs Toledo moneyline has Louisville as a -334 favorite, while Toledo is a +270 underdog.

Louisville vs. Toledo Points Insights

Louisville vs. Toledo Game Info

• Game day: Tuesday, December 23, 2025
• Game time: 2 p.m. ET
• TV channel: ESPN
• Location: Boca Raton, Florida
• Stadium: Flagler Credit Union Stadium

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Check out even more in-depth Louisville vs. Toledo analysis on FanDuel Research.