Louisville vs SMU College Basketball Prediction, Odds, Picks, Best Bets for Feb. 17

The Louisville Cardinals (19-6, 8-4 ACC) aim to extend a five-game winning streak when they visit the SMU Mustangs (17-8, 6-6 ACC) on February 17, 2026 at Moody Coliseum.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. SMU Game Info and Odds

• Game day: Tuesday, February 17, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN2
• Location: Dallas, Texas
• Arena: Moody Coliseum

Take a look at some betting trends for Louisville (-4.5) versus SMU on Tuesday. The over/under has been set at 167.5 points for this game.

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Louisville vs. SMU: ATS Betting Stats and Trends

• Louisville has compiled a 14-11-0 record against the spread this season.
• SMU is 11-14-0 ATS this year.
• Louisville (13-7) covers a higher percentage of games when it is favored by 4.5 points or more this season (65%) than SMU (1-2) does as a 4.5+-point underdog (33.3%).
• Against the spread, the Cardinals have played better when playing at home, covering nine times in 15 home games, and two times in seven road games.
• In 2025-26 against the spread, the Mustangs have a lower winning percentage at home (.400, 6-9-0 record) than on the road (.500, 4-4-0).
• Louisville has five wins against the spread in 12 conference games this season.
• SMU's ACC record against the spread is 5-7-0.

Louisville vs. SMU: Moneyline Betting Stats

• Louisville has been the moneyline favorite in 16 games this season and has come away with the win 13 times (81.2%) in those contests.
• The Cardinals have a win-loss record of 12-2 when favored by -205 or better by oddsmakers this year.
• SMU is 2-7 in games it was the underdog on the moneyline (winning 22.2% of those games).
• The Mustangs have not yet won a game when it entered play as a moneyline underdog with odds of +172 or longer in three chances.
• The moneyline set for this matchup implies Louisville has a 67.2% chance of walking away with the win.

Louisville vs. SMU Head-to-Head Comparison

• Last season, Louisville was 65th in college basketball on offense (78.5 points scored per game) and 89th on defense (69.5 points allowed).
• At 34.6 rebounds per game and 30.2 rebounds allowed, Louisville was 47th and 114th in the nation, respectively, last season.
• Louisville was 148th in the nation in assists (13.9 per game) last season.
• Louisville committed 10.9 turnovers per game last year and forced 12.2 per game, ranking 150th and 93rd, respectively, in college basketball.
• With 79.9 points per game on offense, SMU was 40th in the country last season. On defense, it allowed 71.3 points per contest, which ranked 152nd in college basketball.
• SMU ranked 43rd in the nation with 34.7 boards per game. Meanwhile, it ranked 53rd with 29 rebounds allowed per contest.
• Last season SMU ranked 42nd in college basketball in assists, delivering 15.9 per game.
• Last season SMU averaged 11.5 turnovers per game (221st-ranked in college basketball) and forced 12 turnovers per contest (112th-ranked).

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