Louisville vs Notre Dame College Basketball Prediction, Odds, Picks, Best Bets for Feb. 4

The Notre Dame Fighting Irish (11-11, 2-7 ACC) aim to break a four-game road losing streak when they visit the Louisville Cardinals (15-6, 5-4 ACC) on February 4, 2026.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Notre Dame Game Info and Odds

• Game day: Wednesday, February 4, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN2
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

Check out the betting trends and insights below before placing a bet on Wednesday's Louisville-Notre Dame spread (Louisville -18.5) or total (155.5 points).

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Louisville vs. Notre Dame: ATS Betting Stats and Trends

• Louisville has won 12 games against the spread this season, while failing to cover nine times.
• Notre Dame has won 10 games against the spread this season, while failing to cover 11 times.
• The Cardinals have done a better job covering the spread in home games (8-5-0) than they have in road games (2-4-0).
• The Fighting Irish's winning percentage against the spread at home is .455 (5-6-0). On the road, it is .571 (4-3-0).
• Louisville has four wins against the spread in nine conference games this year.
• Against the spread in ACC action, Notre Dame is 3-6-0 this season.

Louisville vs. Notre Dame: Moneyline Betting Stats

• Louisville has won in nine, or 75%, of the 12 contests it has been named as the moneyline favorite in this year.
• The Cardinals have played as a favorite of -3448 or more just one time this year and came away with a win in that game.
• Notre Dame has won 23.1% of the games this season it was the moneyline underdog (3-10).
• The Fighting Irish have not yet played a game with moneyline odds of +1280 or longer.
• The moneyline set for this matchup implies Louisville has a 97.2% chance of walking away with the win.

Louisville vs. Notre Dame Head-to-Head Comparison

• Louisville is outscoring opponents by 15.6 points per game with a +328 scoring differential overall. It puts up 86.1 points per game (23rd in college basketball) and allows 70.5 per outing (89th in college basketball).
• Ryan Conwell paces Louisville, averaging 19.1 points per game (52nd in college basketball).
• Notre Dame puts up 74.0 points per game (243rd in college basketball) while giving up 72.2 per outing (142nd in college basketball). It has a +39 scoring differential and outscores opponents by 1.8 points per game.
• Jalen Haralson is ranked 248th in the nation with a team-leading 15.5 points per game.
• The Cardinals win the rebound battle by 6.9 boards on average. They record 38.0 rebounds per game, which ranks 12th in college basketball, while their opponents grab 31.1 per outing.
• Sananda Fru paces the team with 6.7 rebounds per game (193rd in college basketball action).
• The Fighting Irish grab 33.8 rebounds per game (102nd in college basketball) while conceding 28.4 per outing to opponents. They outrebound opponents by 5.4 boards per game.
• Carson Towt averages 9.5 rebounds per game (24th in college basketball) to lead the Fighting Irish.
• Louisville ranks 27th in college basketball by averaging 106.2 points per 100 possessions on offense, and defensively is 35th in college basketball, allowing 87.0 points per 100 possessions.
• The Fighting Irish rank 166th in college basketball with 98.6 points scored per 100 possessions, and 239th defensively with 96.2 points conceded per 100 possessions.

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