Louisville vs North Carolina College Basketball Prediction, Odds, Picks for Feb. 23

The North Carolina Tar Heels (21-6, 9-5 ACC) will attempt to extend a 16-game home win streak when they host the Louisville Cardinals (20-7, 9-5 ACC) on February 23, 2026 at Dean E. Smith Center.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. North Carolina Game Info and Odds

• Game day: Monday, February 23, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Chapel Hill, North Carolina
• Arena: Dean E. Smith Center

Louisville is a 4.5-point favorite over North Carolina on Monday and the total has been set at 162.5 points. Below are a few betting insights and trends if you are planning on making a wager on the matchup.

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Louisville vs. North Carolina: ATS Betting Stats and Trends

• Louisville is 14-13-0 ATS this season.
• North Carolina is 14-13-0 ATS this year.
• North Carolina covers the spread when it is a 4.5-point underdog or more 75% of the time. That's more often than Louisville covers as a favorite of 4.5 or more (59.1%).
• The Cardinals have done a better job covering the spread at home (9-7-0) than they have in road games (2-6-0).
• Against the spread, the Tar Heels have been better at home (9-6-0) than on the road (4-5-0).
• Louisville's record against the spread in conference games is 5-9-0.
• North Carolina is 6-8-0 against the spread in ACC play this year.

Louisville vs. North Carolina: Moneyline Betting Stats

• Louisville has come away with 14 wins in the 18 contests it has been listed as the moneyline favorite in this season.
• The Cardinals have a mark of 13-3 in contests where sportsbooks favor them by -196 or better on the moneyline.
• North Carolina has won four of the seven games it was listed as the moneyline underdog this season (57.1%).
• In games they have played as a moneyline underdog with odds of +162 or longer, the Tar Heels have a record of 3-1 (75%).
• The moneyline set for this matchup implies Louisville has a 66.2% chance of walking away with the win.

Louisville vs. North Carolina Head-to-Head Comparison

• Offensively, Louisville was the 65th-ranked team in the country (78.5 points per game) last year. On defense, it was 89th (69.5 points conceded per game).
• On the boards, Louisville was 47th in college basketball in rebounds (34.6 per game) last year. It was 114th in rebounds allowed (30.2 per game).
• Louisville was 148th in the country in assists (13.9 per game) last year.
• At 10.9 turnovers committed per game and 12.2 turnovers forced last year, Louisville was 150th and 93rd in college basketball, respectively.
• Last season North Carolina scored 80.7 points per game (29th-ranked in college basketball) and allowed 74.7 points per contest (261st-ranked).
• North Carolina averaged 33.2 rebounds per game (105th-ranked in college basketball). It gave up 31.2 rebounds per contest (182nd-ranked).
• North Carolina put up 14.7 dimes per game, which ranked them 93rd in the country.
• North Carolina averaged 10.5 turnovers per game (120th-ranked in college basketball). It forced 10.2 turnovers per contest (288th-ranked).

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