Lakers vs. Spurs Prediction, Odds, Picks, Best Bets for Dec. 10

Lakers vs. Spurs Game Info

• Date: Wednesday, December 10, 2025
• Time: 10 p.m. ET
• Venue: Crypto.com Arena -- Los Angeles, California
• Coverage: Amazon Prime Video and SportsNet LA

The Los Angeles Lakers (17-6) are favored by 4.5 points against the San Antonio Spurs (16-7) on Wednesday, December 10, 2025 at 10 p.m. ET. The matchup airs on Amazon Prime Video and SportsNet LA. The over/under is set at 234.5 for the matchup.

Lakers vs. Spurs Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Lakers vs. Spurs Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Lakers win (63.4%)

Lakers vs. Spurs Betting Trends

• The Lakers have covered the spread 15 times in 23 games with a set spread.
• In the Spurs' 23 games this season, they have 10 wins against the spread.
• Lakers games have gone over the total 16 times this season.
• Spurs games this year have gone over the point total 13 times in 23 opportunities (56.5%).
• In home games, Los Angeles owns a worse record against the spread (6-4-0) compared to its ATS record in road games (9-4-0).
• The Lakers have gone over the total in a higher percentage of home games (100%) than road games (46.2%).
• Against the spread, San Antonio has been better at home (6-3-2) than away (4-7-1).
• In terms of the over/under, Spurs games have gone over less often at home (five of 11, 45.5%) than on the road (eight of 12, 66.7%).

Lakers Leaders

• Luka Doncic averages 35 points, 9.2 rebounds and 9.1 assists.
• Austin Reaves is averaging 28.4 points, 5.5 rebounds and 6.7 assists. Defensively, he averages 1.1 steals and 0.2 blocked shots.
• Deandre Ayton's numbers on the season are 15.3 points, 8.8 boards and 0.9 assists per contest, shooting 70.6% from the floor (second in NBA).
• Rui Hachimura averages 14 points, 3.9 rebounds and 0.8 assists, shooting 53.6% from the field and 46.2% from downtown (seventh in league), with 2 made treys per game.
• Jake Laravia is averaging 8.9 points, 3.8 rebounds and 1.8 assists. At the other end, he averages 1.2 steals and 0.3 blocked shots.

Spurs Leaders

• Devin Vassell averages 15.7 points for the Spurs, plus 3.7 boards and 2.4 assists.
• The Spurs receive 24.3 points per game from De'Aaron Fox, plus 3.7 boards and 6.5 assists.
• Keldon Johnson averages 13 points, 6.5 boards and 1.8 assists. He is sinking 57.5% of his shots from the floor (10th in league).
• Per game, Harrison Barnes gives the Spurs 13.4 points, 3.4 boards and 2.2 assists, plus 1 steal and 0.2 blocks.
• The Spurs are getting 11.2 points, 5.3 boards and 1.4 assists per game from Julian Champagnie.

For more NBA betting insights, check out FanDuel Research's NBA home page.

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