Kyren Williams Fantasy Football Week 5: Stats and Projections vs. 49ers

Los Angeles Rams RB Kyren Williams will be up against the 17th-ranked tun defense of the San Francisco 49ers (115.5 yards conceded per game) in Week 5, at 8:15 p.m. ET on Thursday.

With Williams' next game against the 49ers, should you consider him for your DFS lineup? Scroll down for more stats and information.

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Kyren Williams Week 5 Fantasy Football Projection

• Matchup: Los Angeles Rams vs. San Francisco 49ers
• Game Date: October 2, 2025
• Game Time: 8:15 p.m.
• Projected Fantasy Points: 12.6
• PPR Projected Fantasy Points: 13.6
• Projected Rushing Yards: 68.89
• Projected Rushing TDs: 0.70
• Projected Receiving Yards: 12.82
• Projected Receiving TDs: 0.08

Projections provided by numberFire

Williams Fantasy Performance

• Williams is the 18th-ranked fantasy player at the RB position and 54th overall, as he has posted 45.5 total fantasy points (11.4 per game).
• Looking at his last three games, Williams has generated 32.6 fantasy points (10.9 per game) as he's rushed for 237 yards and scored zero touchdowns on 50 carries. As a pass-catcher, he's chipped in with 49 yards on seven grabs (nine targets) with one TDs.
• The high point of Williams' fantasy campaign was a Week 3 outburst versus the Philadelphia Eagles, a game where he went off for zero passing yards and zero touchdowns with picks (for 17.2 total fantasy points). On the ground, he chipped in with 94 rushing yards on 20 attempts (4.7 yards per carry) .
• From a fantasy standpoint, Kyren Williams disappointed his fantasy managers against the Indianapolis Colts last week, when he mustered only 7.4 fantasy points (13 carries, 77 yards). It was his worst fantasy performance of the season.

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49ers Defensive Performance

• Not a single QB has registered more than 300 yards passing in a game against San Francisco this season.
• The 49ers have given up at least one passing TD to three opposing QBs this season.
• San Francisco has given up at least two passing TDs to one opposing QB this year.
• The 49ers have allowed one player to pass for at least three touchdowns in a game this season.
• San Francisco has allowed one player to pick up more than 100 yards receiving in a game this year.
• The 49ers have given up a touchdown reception by five players this year.
• San Francisco has not allowed an opposing player to catch two or more touchdown passes in a game this year.
• The 49ers have given up more than 100 yards rushing to one player this season.
• A total of two players have rushed for at least one touchdown versus San Francisco this year.
• No player has run for more than one touchdown versus the 49ers this season.

Want more data and analysis on Kyren Williams? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.