Kyren Williams Fantasy Football Week 10: Stats and Projections vs. 49ers

In Week 10 (Sunday at 4:25 p.m. ET), RB Kyren Williams and the Los Angeles Rams will meet the San Francisco 49ers, who have the 16th-ranked run defense in the league (108.9 yards conceded per game).

Thinking about Williams for your daily fantasy lineup, with his next game versus the 49ers? We've got stats and information for you in this article.

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Kyren Williams Week 10 Fantasy Football Projection

• Matchup: Los Angeles Rams at San Francisco 49ers
• Game Date: November 9, 2025
• Game Time: 4:25 p.m.
• Projected Fantasy Points: 12.8
• PPR Projected Fantasy Points: 14.2
• Projected Rushing Yards: 63.53
• Projected Rushing TDs: 0.62
• Projected Receiving Yards: 18.91
• Projected Receiving TDs: 0.17

Projections provided by numberFire

Williams Fantasy Performance

• Among players at the RB position, Williams is currently the 11th-ranked player in fantasy (38th overall), with 107.2 total fantasy points (13.4 per game).
• Looking at his last three games, Williams has generated 38.6 fantasy points (12.9 per game) as he's rushed for 218 yards and scored two touchdowns on 50 carries. As a pass-catcher, he's chipped in with 48 yards on four grabs (five targets).
• Williams has 69.1 total fantasy points (13.8 per game) in his last five games, carrying the ball 77 times for 360 yards with two touchdowns. As a pass-catcher, he has added 131 yards on 15 catches (19 targets) with two TDs.
• The high point of Williams' season as a fantasy producer came against the San Francisco 49ers in Week 5, as he tallied 23.1 fantasy points by passing for zero yards and zero passing touchdowns with picks. As a runner, he contributed 65 rushing yards on 14 carries (4.6 YPC) .
• From a fantasy perspective, Kyren Williams had his worst performance of the season in Week 7 against the Jacksonville Jaguars, when he tallied just 6.5 fantasy points (12 carries, 54 yards).

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49ers Defensive Performance

• Two players have recorded over 300 yards passing in a game against San Francisco this season.
• A total of Eight players have thrown for at least one TD against the 49ers this season.
• A total of five players have thrown for two or more TDs versus San Francisco this season.
• The 49ers have given up three or more passing TDs to two opposing QBs this season.
• San Francisco has given up more than 100 yards receiving to just one player this season.
• A total of 14 players have caught a TD pass versus the 49ers this season.
• Only one player has caught more than one touchdown pass against San Francisco this season.
• The 49ers have allowed only one player to put up over 100 yards rushing in a game this season.
• San Francisco has allowed five players to score at least one rushing touchdown versus them this year.
• The 49ers have not given up more than one rushing TD to an opposing player this season.

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