Kyler Murray Fantasy Football Week 6: Stats and Projections vs. Colts

Kyler Murray and the Arizona Cardinals will play the Indianapolis Colts and their 19th-ranked passing defense (217 yards allowed per game) in Week 6, on Sunday at 1 p.m. ET.

With Murray's next game versus the Colts, should you consider him for your DFS roster? See below for more stats and information.

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Kyler Murray Week 6 Fantasy Football Projection

• Matchup: Arizona Cardinals at Indianapolis Colts
• Game Date: October 12, 2025
• Game Time: 1 p.m.
• Projected Fantasy Points: 17.1
• Projected Passing Yards: 226.85
• Projected Passing TDs: 1.16
• Projected Rushing Yards: 35.02
• Projected Rushing TDs: 0.31

Projections provided by numberFire

Murray Fantasy Performance

• With 77.8 fantasy points in 2025 (15.6 per game), Murray is the 17th-ranked fantasy player at his position and 23rd overall.
• Through his last three games, Murray has completed 72-of-107 throws for 579 yards, with three passing touchdowns and two interceptions, resulting in 45.5 total fantasy points (15.2 per game). With his legs, he's added 103 rushing yards on 15 attempts with one TD.
• The high point of Murray's fantasy season so far was Week 1 against the New Orleans Saints, when he carried seven times for 38 yards on his way to 18.3 fantasy points.
• From a fantasy standpoint, Kyler Murray stumbled to his worst performance of the season in Week 2 against the Carolina Panthers, throwing for 220 yards and one touchdown with one interception with 32 yards on seven attempts on the ground (14.0 fantasy points).

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Colts Defensive Performance

• Indianapolis has allowed just one player to record more than 300 yards passing in a game this season.
• A total of Four players have thrown for at least one TD against the Colts this year.
• A total of two players have thrown for at least two touchdowns versus Indianapolis this year.
• The Colts have given up three or more passing touchdowns to two opposing QBs this year.
• A total of one player has collected over 100 yards receiving in a game versus Indianapolis this year.
• The Colts have given up a touchdown reception by eight players this year.
• Indianapolis has not allowed an opposing player to catch two or more touchdown passes in a game this season.
• The Colts' defense has not allowed a player to pile up more than 100 yards rushing in a game this year.
• Indianapolis has given up at least one rushing TD to two players this year.
• No player has rushed for more than one touchdown versus the Colts this year.

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