Knicks vs. Cavaliers Prediction, Odds, Picks, Best Bets for Oct. 22

Knicks vs. Cavaliers Game Info

• Date: Wednesday, October 22, 2025
• Time: 7 p.m. ET
• Venue: Madison Square Garden -- New York City, New York
• Coverage: ESPN and MSG

The Cleveland Cavaliers visit the New York Knicks for both team's first outing of the 2025-26 season. The contest will starting at 7 p.m. ET on Wednesday, October 22, 2025 at Madison Square Garden. The Cavaliers are 3.5-point favorites in the game. The over/under is 227.5 for the matchup.

Knicks vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Knicks vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Knicks win (53%)

Knicks vs. Cavaliers Betting Trends

• The Cavaliers covered 47 times in 82 chances against the spread last season.
• As 3.5-point underdogs or greater, the Knicks went 3-8 against the spread last season.
• A total of 50 Cavaliers games last season went over the point total.
• The Knicks had 43 of their 82 games hit the over last year.
• In home games last season, Cleveland had a worse record against the spread (23-17-1) compared to its ATS record in road games (24-16-1).
• In 2024-25 against the spread, New York had a better winning percentage at home (.512, 21-19-1 record) than on the road (.463, 19-22-0).

Cavaliers Leaders

• Donovan Mitchell posted 24.0 points, 4.5 rebounds and 5.0 assists last year. He also sank 44.3% of his shots from the field and 36.8% from beyond the arc, with 3.3 triples per contest (eighth in NBA).
• Per game, Evan Mobley collected 18.5 points, 9.3 rebounds and 3.2 assists. He also put up 0.9 steals and 1.6 blocks (fourth in NBA).
• Darius Garland recorded 20.6 points, 2.9 rebounds and 6.7 assists. He made 47.2% of his shots from the floor and 40.1% from beyond the arc, with 2.8 triples per contest.
• Jarrett Allen averaged 13.5 points, 9.7 rebounds and 1.9 assists per contest, plus 0.9 steals and 0.9 blocks.
• De'Andre Hunter's stats last season included 17.0 points, 4.0 boards and 1.4 assists per game. He sank 47.0% of his shots from the floor and 40.5% from 3-point range, with an average of 2.5 treys.

Knicks Leaders

• Karl-Anthony Towns averaged 24.4 points last season, plus 3.1 assists and 12.8 rebounds.
• Josh Hart's numbers last season were 13.6 points, 9.6 boards and 5.9 assists per contest, shooting 52.5% from the floor and 33.3% from beyond the arc, with an average of 1.1 made 3-pointers.
• Jalen Brunson collected 26.0 points, 2.9 boards and 7.3 assists, shooting 48.8% from the floor and 38.3% from beyond the arc, with 2.3 made 3-pointers per contest.
• Mikal Bridges posted 17.6 points, 3.2 boards and 3.7 assists.
• OG Anunoby put up 18.0 points, 4.8 rebounds and 2.2 assists, shooting 47.6% from the field and 37.2% from downtown, with 2.3 made treys per contest.

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