James Cook Fantasy Football Week 5: Stats and Projections vs. Patriots

James Cook and the Buffalo Bills will meet the New England Patriots and their second-ranked run defense (77.5 yards allowed per game) in Week 5, on Sunday at 8:20 p.m. ET.

For more details on Cook, if you're considering him for your daily fantasy roster, check out this article prior to his upcoming matchup versus the Patriots.

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James Cook Week 5 Fantasy Football Projection

• Matchup: Buffalo Bills vs. New England Patriots
• Game Date: October 5, 2025
• Game Time: 8:20 p.m.
• Projected Fantasy Points: 16.6
• PPR Projected Fantasy Points: 17.8
• Projected Rushing Yards: 92.73
• Projected Rushing TDs: 0.75
• Projected Receiving Yards: 22.67
• Projected Receiving TDs: 0.12

Projections provided by numberFire

Cook Fantasy Performance

• Cook has been coming through for fantasy managers this season, as his 79 fantasy points (19.8 per game) rank him fourth at the RB position and 18th overall.
• In his last three games, Cook has put up 62.8 fantasy points (20.9 per game), running for 357 yards and scoring four touchdowns on 62 carries. He has also helped out in the passing game with 31 yards on seven grabs (eight targets) as a receiver.
• The peak of Cook's season as a fantasy producer came against the New York Jets in Week 2, as he put up 25.5 fantasy points by grabbing one pass (on one target) for three yards.
• From a fantasy standpoint, James Cook disappointed his fantasy managers against the Baltimore Ravens in Week 1, when he mustered only 16.2 fantasy points (13 carries, 44 yards, 1 TD; 5 receptions, 58 yards). It was his worst fantasy effort of the year.

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Patriots Defensive Performance

• New England has allowed two players to put up more than 300 yards passing in a game this season.
• The Patriots have given up at least one passing TD to five opposing QBs this year.
• New England has allowed two or more TD passes to two opposing QBs this year.
• The Patriots have not allowed more than two passing touchdowns to an opposing quarterback this year.
• New England has allowed two players to amass more than 100 yards receiving in a game this year.
• The Patriots have given up a TD reception by seven players this year.
• No player has hauled in more than one touchdown pass versus New England this year.
• No player has recorded over 100 yards on the ground in a game versus the Patriots this year.
• A total of two players have rushed for at least one touchdown versus New England this season.
• The Patriots have not allowed an opposing player to score more than one rushing TD versus them this year.

Want more data and analysis on James Cook? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.