James Cook Fantasy Football Week 16: Stats and Projections vs. Browns

Buffalo Bills RB James Cook will be up against the 14th-ranked tun defense of the Cleveland Browns (110.1 yards allowed per game) in Week 16, at 1 p.m. ET on Sunday.

Is Cook a daily fantasy option for you this week, as he faces the Browns? More stats and information can be found in this article, so take a look.

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James Cook Week 16 Fantasy Football Projection

• Matchup: Buffalo Bills at Cleveland Browns
• Game Date: December 21, 2025
• Game Time: 1 p.m.
• Projected Fantasy Points: 14.5
• PPR Projected Fantasy Points: 15.4
• Projected Rushing Yards: 92.92
• Projected Rushing TDs: 0.64
• Projected Receiving Yards: 14.07
• Projected Receiving TDs: 0.08

Projections provided by numberFire

Cook Fantasy Performance

• Cook has been one of the best players in fantasy at the RB position this season, ranking fourth with 16.8 fantasy points per game (234.6 total points). He is 16th in fantasy points among all players.
• In his last three games, Cook has posted 53.9 fantasy points (18.0 per game), rushing for 331 yards and scoring two touchdowns on 72 carries. He has also helped out in the passing game with 68 yards on seven grabs (eight targets) with one TDs as a pass-catcher.
• Cook has put up 90.2 fantasy points (18.0 per game) over his last five games, running for 495 yards with three touchdowns on 105 carries. He has also contributed 147 yards on 13 catches (14 targets) with two TDs as a pass-catcher.
• The high point of Cook's fantasy season came against the Carolina Panthers in Week 8, when he piled up 33.6 fantasy points with zero passing yards, zero TDs, and picks. With his legs, he added 216 rushing yards on 19 carries (11.4 YPC) with two touchdowns.
• From a fantasy standpoint, James Cook had his worst performance of the season in Week 5 against the New England Patriots, when he put up just 4.9 fantasy points (15 carries, 49 yards).

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Browns Defensive Performance

• Cleveland has not allowed a player to record over 300 yards passing in a game this year.
• The Browns have allowed 13 players to pass for at least one TD in a game this year.
• Cleveland has allowed six players to pass for at least two touchdowns in a game this season.
• The Browns have given up three or more passing touchdowns to just two opposing QBs this season.
• Cleveland has given up over 100 yards receiving to just one player this year.
• A total of 19 players have caught a touchdown pass versus the Browns this season.
• A total of three players have hauled in more than one TD pass versus Cleveland this year.
• The Browns have given up more than 100 yards rushing to only two players this season.
• Cleveland has allowed nine players to score at least one rushing TD versus them this season.
• The Browns have allowed only two players to score more than one rushing TD in a game this year.

Want more data and analysis on James Cook? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.