Islanders vs Sharks NHL Prediction, Odds, Picks, Best Bets for Oct. 21

Tuesday's slate in the NHL includes a matchup between the New York Islanders and the San Jose Sharks.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NHL betting insights.

Islanders vs Sharks Game Info

• New York Islanders (2-3) vs. San Jose Sharks (0-3-2)
• Date: Tuesday, October 21, 2025
• Time: 7 p.m. ET
• Venue: UBS Arena -- Elmont, New York
• Coverage: ESPN+

Islanders vs Sharks Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Islanders vs Sharks Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Islanders win (58.5%)

Islanders vs Sharks Puck Line

• The Islanders are favored by 1.5 goals against the Sharks. The Islanders are +110 to cover the spread, while the Sharks are -134.

Islanders vs Sharks Over/Under

• An over/under of 6.5 has been set for Islanders-Sharks on Oct. 21, with the over being -110 and the under -110.

Islanders vs Sharks Moneyline

• Looking at the moneyline for Islanders-Sharks, New York is the favorite at -225, and San Jose is +184 playing on the road.

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