Islanders vs Blues NHL Prediction, Odds, Picks, Best Bets for Nov. 22

The New York Islanders are among the NHL teams playing on Saturday, versus the St. Louis Blues.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NHL betting insights.

Islanders vs Blues Game Info

• New York Islanders (12-7-2) vs. St. Louis Blues (6-9-6)
• Date: Saturday, November 22, 2025
• Time: 3:30 p.m. ET
• Venue: UBS Arena -- Elmont, New York
• Coverage: ESPN+

Islanders vs Blues Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Islanders vs Blues Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Islanders win (57.3%)

Islanders vs Blues Puck Line

• The Islanders are favored by 1.5 goals (+186 to cover). St. Louis, the underdog, is -235.

Islanders vs Blues Over/Under

• An over/under of 5.5 has been set for Islanders-Blues on Nov. 22, with the over being -134 and the under +110.

Islanders vs Blues Moneyline

• Looking at the moneyline for Blues-Islanders, St. Louis is the underdog at +108, and New York is -130 playing at home.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!