Iowa vs Penn State Prediction, Odds, Picks, Best Bets for Week 8 2025

The Iowa Hawkeyes versus the Penn State Nittany Lions is on the college football schedule for Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Iowa vs Penn State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa: (-156) | Penn State: (+132)
• Spread: Iowa: -3.5 (-102) | Penn State: +3.5 (-120)
• Total: 41.5 -- Over: (-105) | Under: (-115)

Iowa vs Penn State Betting Trends

• Iowa has covered the spread five times in six games.
• Iowa has two wins ATS (2-1) as a 3.5-point or higher favorite in 2025.
• Two of six Iowa games have gone over the point total this season.
• Penn State has no wins against the spread this year.
• There have been four Penn State games (out of six) that hit the over this year.

Iowa vs Penn State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (52%)

Iowa vs Penn State Point Spread

Penn State is listed as an underdog by 3.5 points (-120 odds), and Iowa, the favorite, is -102 to cover.

Iowa vs Penn State Over/Under

A total of 41.5 points has been set for the Iowa-Penn State game on Oct. 18, with the over available at -105 and the under at -115.

Iowa vs Penn State Moneyline

Looking at the moneyline for Iowa-Penn State, Iowa is the favorite at -156, and Penn State is +132.

Iowa vs. Penn State Points Insights

Iowa vs. Penn State Game Info

• Game day: Saturday, October 18, 2025
• Game time: 7 p.m. ET
• TV channel: Peacock
• Location: Iowa City, Iowa
• Stadium: Kinnick Stadium

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Check out even more in-depth Iowa vs. Penn State analysis on FanDuel Research.