Iowa State vs Colorado Prediction, Odds, Picks, Best Bets for Week 7 2025

In college football action on Saturday, the Iowa State Cyclones play the Colorado Buffaloes.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info about today's NCAA football betting odds.

Iowa State vs Colorado Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-154) | Colorado: (+130)
• Spread: Iowa State: -2.5 (-124) | Colorado: +2.5 (102)
• Total: 51.5 -- Over: (-115) | Under: (-105)

Iowa State vs Colorado Betting Trends

• Against the spread, Iowa State is 3-3-0 this year.
• Iowa State has won twice ATS (2-2) as a 2.5-point or bigger favorite this year.
• Out of six Iowa State games so far this season, three have gone over the total.
• Colorado has three wins in six contests against the spread this season.
• Colorado has one win ATS (1-3) as a 2.5-point underdog or more this year.
• Colorado has played two games (out of six) which finished over the total this year.

Iowa State vs Colorado Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (50.7%)

Iowa State vs Colorado Point Spread

Colorado is listed as an underdog by 2.5 points (+102 odds), and Iowa State, the favorite, is -124 to cover.

Iowa State vs Colorado Over/Under

A combined point total of 51.5 has been set for Iowa State-Colorado on Oct. 11, with the over at -115 and the under at -105.

Iowa State vs Colorado Moneyline

Iowa State is a -154 favorite on the moneyline, while Colorado is a +130 underdog.

Iowa State vs. Colorado Points Insights

Iowa State vs. Colorado Game Info

• Game day: Saturday, October 11, 2025
• Game time: 3:30 p.m. ET
• TV channel: ESPN
• Location: Boulder, Colorado
• Stadium: Folsom Field

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Check out even more in-depth Iowa State vs. Colorado analysis on FanDuel Research.