Indiana vs Purdue Prediction, Odds, Picks, Best Bets for Week 14 2025

Friday's slate in college football includes a matchup between the Indiana Hoosiers and the Purdue Boilermakers.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Indiana vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Indiana: (-10000) | Purdue: (+2400)
• Spread: Indiana: -28.5 (-110) | Purdue: +28.5 (-110)
• Total: 54.5 -- Over: (-110) | Under: (-110)

Indiana vs Purdue Betting Trends

• Against the spread, Indiana is 6-5-0 this year.
• Indiana has two wins ATS (2-1) as a 28.5-point or higher favorite in 2025.
• Indiana has played 11 games this year, and seven of them have gone over the total.
• Against the spread, Purdue is 5-6-0 this year.
• Purdue is unbeaten ATS (1-0) as a 28.5-point underdog or more this year.
• Purdue has seen three of its 11 games go over the point total.

Indiana vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hoosiers win (98%)

Indiana vs Purdue Point Spread

Purdue is the underdog by 28.5 points against Indiana. Purdue is -110 to cover the spread, and Indiana is -110.

Indiana vs Purdue Over/Under

Indiana versus Purdue on Nov. 28 has an over/under of 54.5 points, with the over -110 and the under -110.

Indiana vs Purdue Moneyline

Indiana is the favorite, -10000 on the moneyline, while Purdue is a +2400 underdog.

Indiana vs. Purdue Points Insights

Indiana vs. Purdue Game Info

• Game day: Friday, November 28, 2025
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: West Lafayette, Indiana
• Stadium: Ross-Ade Stadium

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