Houston vs Notre Dame College Basketball Prediction, Odds, Picks, Best Bets for Nov. 26

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The Houston Cougars (6-1) take the court against the Notre Dame Fighting Irish (5-2) on November 26, 2025.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Houston vs. Notre Dame Game Info and Odds

Before making a bet on Wednesday's Houston-Notre Dame spread (Houston -11.5) or total (132.5 points), read the betting insights and trends below.

Houston has won two games against the spread this season.
Notre Dame has won two games against the spread this year.
The Cougars sported a worse record against the spread when playing at home (10-7-0) than they did in road games (7-3-0) last season.
The Fighting Irish's winning percentage against the spread at home last season was .438 (7-9-0). Away, it was .417 (5-7-0).

Houston has been chosen as the moneyline favorite in four games this year and has walked away with the win three times (75%) in those games.
The Cougars have been listed as a favorite of -952 or more on two occasions this season and won both games.
Notre Dame has been listed as the moneyline underdog only two other times so far this season, and it lost both games.
The Fighting Irish have yet to play a game with moneyline odds of +610 or longer.
The moneyline set for this matchup implies Houston has a 90.5% chance of walking away with the win.

Last year, Houston was 182nd in the country on offense (73.7 points scored per game) and best defensively (58.7 points conceded).
On the boards, Houston was 96th in college basketball in rebounds (33.3 per game) last year. It was 10th-best in rebounds allowed (26.9 per game).
Houston was 292nd in the country in assists (12 per game) last year.
In terms of turnovers, Houston was third-best in the nation in committing them (8.4 per game) last year. It was 85th in forcing them (12.3 per game).
Last year Notre Dame averaged 72.6 points per game (212th-ranked in college basketball) and ceded 72.5 points per contest (195th-ranked).
Notre Dame pulled down 31.6 rebounds per game (194th-ranked in college basketball) last year, while allowing 29.1 rebounds per contest (56th-ranked).
Notre Dame put up 11.4 dimes per game, which ranked them 323rd in the nation.
Notre Dame ranked 98th in the country at 10.3 turnovers per game, but it forced 9.5 turnovers per game, which ranked 25th-worst in college basketball.

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