Illinois vs Missouri College Basketball Prediction, Odds, Picks, Best Bets for Dec. 22

3mo

Subscribe to our newsletter

The Missouri Tigers (10-2) hope to build on a nine-game home winning streak when they host the Illinois Fighting Illini (8-3) on December 22, 2025.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Illinois vs. Missouri Game Info and Odds

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Illinois win (66.5%)

Take a look at these betting insights and trends before you bet on Monday's Illinois-Missouri spread (Illinois -9.5) or total (155.5 points).

Illinois is 6-5-0 ATS this season.
Missouri is 5-7-0 ATS this season.
The Fighting Illini covered the spread in a higher percentage of their home games than away games last season. They covered 10 times in 17 opportunities at home, and they covered five times in 10 opportunities in away games.
The Tigers' winning percentage against the spread at home last year was .579 (11-8-0). On the road, it was .500 (5-5-0).

Illinois has come away with four wins in the six contests it has been listed as the moneyline favorite in this season.
The Fighting Illini have a mark of 2-1 in contests where oddsmakers favor them by -610 or better on the moneyline.
Missouri has been the moneyline underdog just one other time so far this season, a game it lost.
The Tigers have yet to play as a moneyline underdog of +440 or longer.
Illinois has an implied victory probability of 85.9% according to the moneyline set for this matchup.

Illinois has a +179 scoring differential, topping opponents by 16.3 points per game. It is putting up 87.8 points per game to rank 35th in college basketball and is allowing 71.5 per outing to rank 138th in college basketball.
Illinois' leading scorer, Kylan Boswell, ranks 188th in college basketball averaging 16.1 points per game.
Missouri has a +203 scoring differential, topping opponents by 17.0 points per game. It is putting up 86.8 points per game, 44th in college basketball, and is giving up 69.8 per contest to rank 99th in college basketball.
Mark Mitchell is ranked 74th in college basketball with a team-leading 18.2 points per game.
The Fighting Illini rank 15th in college basketball at 38.8 rebounds per game. That's 10.3 more than the 28.5 their opponents average.
David Mirkovic averages 8.8 rebounds per game (ranking 45th in college basketball) to lead the Fighting Illini.
The Tigers pull down 34.7 rebounds per game (110th in college basketball) while conceding 24.8 per contest to opponents. They outrebound opponents by 9.9 boards per game.
Mitchell paces the team with 6.1 rebounds per game (294th in college basketball).
Illinois ranks 19th in college basketball with 109.8 points scored per 100 possessions, and 121st in college basketball defensively with 89.4 points conceded per 100 possessions.
The Tigers average 109.5 points per 100 possessions on offense (21st in college basketball), and concede 88.2 points per 100 possessions (96th in college basketball).

Want more stories like this?