Houston vs LSU Prediction, Odds, Picks, Best Bets for Texas Bowl 2025

The Houston Cougars are among the college football teams in action on Saturday, versus the LSU Tigers.

We've got you covered, in terms of the vital information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Houston vs LSU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Houston: (-124) | LSU: (+106)
• Spread: Houston: -1.5 (-118) | LSU: +1.5 (-104)
• Total: 41.5 -- Over: (-115) | Under: (-105)

Houston vs LSU Betting Trends

• Houston has eight wins in 12 games against the spread this year.
• Houston owns an ATS record of 5-3 as 1.5-point or greater favorites.
• Out of 12 Houston games so far this season, seven have hit the over.
• LSU has four wins in 12 contests against the spread this year.
• LSU has won twice ATS (2-4) as a 1.5-point underdog or greater this year.
• Of 12 LSU games so far this season, three have hit the over.

Houston vs LSU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (50.8%)

Houston vs LSU Point Spread

Houston is a 1.5-point favorite against LSU. Houston is -118 to cover the spread, and LSU is -104.

Houston vs LSU Over/Under

Houston versus LSU on Dec. 27 has an over/under of 41.5 points, with the over -115 and the under -105.

Houston vs LSU Moneyline

Looking at the moneyline for Houston-LSU, Houston is the favorite at -124, and LSU is +106.

Houston vs. LSU Points Insights

Houston vs. LSU Game Info

• Game day: Saturday, December 27, 2025
• Game time: 9:15 p.m. ET
• TV channel: ESPN
• Location: Houston, Texas
• Stadium: NRG Stadium

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Check out even more in-depth Houston vs. LSU analysis on FanDuel Research.