Houston vs LSU Prediction, Odds, Picks, Best Bets for Texas Bowl 2025

The Houston Cougars versus the LSU Tigers is on the college football schedule for Saturday.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Houston vs LSU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Houston: (-134) | LSU: (+112)
• Spread: Houston: -2.5 (-115) | LSU: +2.5 (-105)
• Total: 41.5 -- Over: (-110) | Under: (-110)

Houston vs LSU Betting Trends

• Against the spread, Houston is 8-4-0 this year.
• Houston's ATS record as 2.5-point or bigger favorites is 4-2.
• There have been seven Houston games (of 12) that went over the total this season.
• LSU is 4-8-0 against the spread this year.
• As a 2.5-point underdog or more, LSU has two wins ATS (2-2).
• LSU has played 12 games this season, and three of them have gone over the total.

Houston vs LSU Point Spread

LSU is a 2.5-point underdog against Houston. LSU is -105 to cover the spread, and Houston is -115.

Houston vs LSU Over/Under

The over/under for the Houston versus LSU game on Dec. 27 has been set at 41.5, with -110 odds on the over and -110 odds on the under.

Houston vs LSU Moneyline

LSU is a +112 underdog on the moneyline, while Houston is a -134 favorite.

Houston vs. LSU Points Insights

Houston vs. LSU Game Info

• Game day: Saturday, December 27, 2025
• Game time: 9:15 p.m. ET
• TV channel: ESPN
• Location: Houston, Texas
• Stadium: NRG Stadium

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Check out even more in-depth Houston vs. LSU analysis on FanDuel Research.