A Sweet 16 matchup features the No. 1 seed Houston Cougars (32-4) squaring off against the No. 4 seed Duke Blue Devils (26-8) on Friday at American Airlines Center. This NCAA Tournament matchup tips at 9:39 PM ET, with the winner moving on to the South Regional final.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Houston vs. Duke Game Info and Odds

• Game Day: Friday, March 29, 2024
• Game Time: 9:39 PM ET
• TV Channel: CBS
• Location: Dallas, Texas
• Arena: American Airlines Center

Houston vs. Duke Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Houston win (52.3%)

Check out the betting insights and trends below before placing a wager on Friday's Houston-Duke spread (Houston -4.5) or over/under (133.5 points).

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Houston vs. Duke: ATS Betting Stats and Trends

• Houston has put together an 18-18-0 record against the spread this season.
• Duke has covered 20 times in 34 matchups with a spread this year.
• Houston covers the spread when it is a 4.5-point favorite or more 51.6% of the time. That's more often than Duke covers as an underdog of 4.5 or more (never covered this season).
• Against the spread, the Cougars have performed better when playing at home, covering 11 times in 17 home games, and two times in 10 road games.
• Against the spread, the Blue Devils have performed better at home (11-7-0) than on the road (5-6-0).

Houston vs. Duke: Moneyline Betting Stats

• Houston has won in 29, or 87.9%, of the 33 contests it has been named as the moneyline favorite in this year.
• The Cougars have a mark of 27-1 in contests where sportsbooks favor them by -194 or better on the moneyline.
• Duke has won one of the three games it was the underdog on the moneyline this season (33.3%).
• The Blue Devils have played as a moneyline underdog of +160 or longer in just two games this season, which they split 1-1.
• Houston has an implied victory probability of 66% according to the moneyline set by sportsbooks for this matchup.

Houston vs. Duke Head-to-Head Comparison

• Houston's +591 scoring differential (outscoring opponents by 16.4 points per game) is a result of scoring 74.1 points per game (155th in college basketball) while allowing 57.7 per outing (first in college basketball).
• Houston's leading scorer, LJ Cryer, is 233rd in college basketball scoring 15.5 points per game.
• Duke outscores opponents by 13.3 points per game (posting 79.8 points per game, 42nd in college basketball, and allowing 66.5 per outing, 30th in college basketball) and has a +452 scoring differential.
• Kyle Filipowski's team-leading 16.6 points per game rank him 151st in the country.
• The Cougars prevail in the rebound battle by an average of 3.5 boards. They are pulling down 37.3 rebounds per game (84th in college basketball) compared to their opponents' 33.8 per outing.
• J'wan Roberts tops the Cougars with 6.8 rebounds per game (194th in college basketball play).
• The Blue Devils are 115th in college basketball at 36.5 rebounds per game. That's 5.1 more than the 31.4 their opponents average.
• Filipowski tops the team with 8.1 rebounds per game (84th in college basketball).
• Houston ranks 78th in college basketball by averaging 99.0 points per 100 possessions on offense, and defensively is first in college basketball, allowing 77.1 points per 100 possessions.
• The Blue Devils rank ninth in college basketball with 105.8 points scored per 100 possessions, and 50th defensively with 88.2 points conceded per 100 possessions.

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