Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for ALDS Game 1 on Oct. 3

Odds updated as of 12:11 p.m.

The Cleveland Guardians versus the Chicago White Sox in Game 1 of the ALDS is on the MLB schedule for Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Guardians vs White Sox Game Info

• Cleveland Guardians (85-77) vs. Chicago White Sox (84-78)
• Date: Saturday, October 3, 2026
• Time: 1 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: truTV, TBS, and HBO Max

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-148) | CHW: (+126)
• Spread: CLE: -1.5 (+152) | CHW: +1.5 (-184)
• Total: 6.5 -- Over: (-128) | Under: (+104)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 12-9, 2.56 ERA vs Hagen Smith (White Sox) - 3-3, 1.29 ERA

The probable starters are Parker Messick (12-9, 2.56 ERA) for the Guardians and Hagen Smith (3-3, 1.29 ERA) for the White Sox. Messick and his team have a record of 16-16-0 against the spread when he starts. Messick's team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 12-12. Smith has started two games with set spreads, and the White Sox went 1-1-0. The White Sox were the underdog on the moneyline for one Smith start this season -- they won.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (55.9%)

Guardians vs White Sox Moneyline

• The Guardians vs White Sox moneyline has Cleveland as a -148 favorite, while Chicago is a +126 underdog on the road.

Guardians vs White Sox Spread

• The Guardians are favored by 1.5 runs at home against the White Sox. The Guardians are +152 to cover the spread, while the White Sox are -184.

Guardians vs White Sox Over/Under

• The over/under for Guardians-White Sox on Oct. 3 is 6.5. The over is -128, and the under is +104.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have been chosen as favorites in 90 games this year and have walked away with the win 48 times (53.3%) in those games.
• Cleveland has a record of 20-9 when favored by -148 or more this year.
• Contests with the Guardians have gone over the total set by sportsbooks in 74 of 152 chances this season.
• The Guardians are 73-79-0 against the spread in their 152 games with a line set by sportsbooks this season.
• The White Sox have won 52 of the 107 games they were the moneyline underdog this season (48.6%).
• When playing as a moneyline underdog with odds of +126 or longer, Chicago has a 16-27 record (winning only 37.2% of its games).
• The White Sox have played in 161 games with a set over/under, and have combined with their opponents to go over the total 91 times (91-69-1).
• The White Sox have covered 57.1% of their games this season, going 92-69-0 ATS.

Guardians Player Leaders

• Chase DeLauter has 142 hits, which leads Cleveland hitters this season, while batting .287 with 49 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .457.
• Among all qualifying hitters in the majors, his batting average ranks 16th, his on-base percentage ranks 24th, and he is 43rd in slugging.
• DeLauter will look for his third straight game with a hit in this contest. In his last five games he is batting .200 with two doubles, a home run, three walks and two RBIs.
• Steven Kwan leads the Guardians with an OPS of .731. He has a slash line of .282/.382/.349 this season.
• His batting average is 21st among qualified players, his on-base percentage seventh, and his slugging percentage 131st.
• Jose Ramirez has 111 hits this season and has a slash line of .235/.320/.368.
• Brayan Rocchio has been key for Cleveland with 135 hits, an OBP of .313 plus a slugging percentage of .391.
• Rocchio has hit safely in two games in a row. In his last five games he is batting .316 with a double, two home runs, a walk and three RBIs.

White Sox Player Leaders

• Miguel Vargas has 31 doubles, a triple, 33 home runs and 101 walks while batting .250. He's slugging .474 with an on-base percentage of .363.
• Including all the qualified hitters in the majors, he ranks 79th in batting average, 24th in on-base percentage and 30th in slugging percentage.
• Chase Meidroth's .415 slugging percentage paces his team. He has a batting average of .276 with an on-base percentage of .350.
• Including all qualifying players, he ranks 33rd in batting average, 45th in on-base percentage and 80th in slugging percentage.
• Sam Antonacci has an on-base percentage of .370, a team-best for the White Sox.
• Munetaka Murakami paces his team with 94 hits.

Guardians vs White Sox Head to Head

• 9/16/2026: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/15/2026: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/3/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/2/2026: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/24/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!