Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 3:12 p.m.

Saturday's slate in the MLB includes a matchup between the Cleveland Guardians and the Minnesota Twins.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Guardians vs Twins Game Info

• Cleveland Guardians (75-73) vs. Minnesota Twins (69-78)
• Date: Saturday, September 12, 2026
• Time: 4:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: Twins.TV and CleGuardians.TV

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-116) | MIN: (-102)
• Spread: CLE: -1.5 (+138) | MIN: +1.5 (-166)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Daniel Espino (Guardians) - 0-0, 2.70 ERA vs Connor Prielipp (Twins) - 4-7, 5.25 ERA

The probable pitchers are Daniel Espino for the Guardians and Connor Prielipp (4-7) for the Twins. Espino did not appear in a game when his team was the moneyline favorite last season. The Twins have a 10-9-0 ATS record in Prielipp's 19 starts with a set spread. The Twins have a 3-11 record in Prielipp's 14 starts this season when they were the underdog on the moneyline.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (53.9%)

Guardians vs Twins Moneyline

• Minnesota is a -102 underdog on the moneyline, while Cleveland is a -116 favorite on the road.

Guardians vs Twins Spread

• The Guardians are at the Twins and are favored by 1.5 runs (+138 to cover) on the runline. Minnesota is -166 to cover.

Guardians vs Twins Over/Under

• The Guardians-Twins game on Sept. 12 has been given an over/under of 7.5 runs. The over is set at -115 and the under at -105.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have been victorious in 43, or 51.2%, of the 84 contests they have been chosen as favorites in this season.
• Cleveland has a record of 41-37 when favored by -116 or more this year.
• The Guardians and their opponents have gone over in 68 of their 140 games with a total set by sportsbooks this season.
• In 140 games with a line this season, the Guardians have a mark of 66-74-0 against the spread.
• The Twins are 38-49 in games they were listed as the moneyline underdog (winning 43.7% of those games).
• In games it has played as a moneyline underdog with odds of -102 or longer, Minnesota has a record of 37-44 (45.7%).
• The Twins have played in 143 games with an over/under set, and have combined with their opponents to go over the total 80 times (80-60-3).
• The Twins have collected a 77-66-0 record against the spread this season (covering 53.8% of the time).

Guardians Player Leaders

• Chase DeLauter has 133 hits, which ranks first among Cleveland hitters this season, while batting .293 with 45 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .460.
• Among qualifying batters in baseball, he ranks 12th in batting average, 24th in on-base percentage, and 38th in slugging.
• Jose Ramirez is batting .232 with 24 doubles, 11 home runs and 57 walks. He's slugging .366 with an on-base percentage of .323.
• Among qualifying hitters, his batting average places him 109th, his on-base percentage 78th, and his slugging percentage 121st.
• Steven Kwan is slashing .274/.372/.335 this season and leads the Guardians with an OPS of .707.
• Kwan takes a five-game hitting streak into this matchup. During his last five outings he is batting .364 with three doubles and a walk.
• Brayan Rocchio is batting .247 with a .307 OBP and 64 RBI for Cleveland this season.

Twins Player Leaders

• Brooks Lee is hitting .246 with 23 doubles, three triples, 23 home runs and 34 walks. He's slugging .432 with an on-base percentage of .295.
• Including all qualified hitters in MLB, his batting average places him 87th, his on-base percentage ranks 123rd, and he is 59th in slugging.
• Josh Bell's .423 slugging percentage leads his team. He has a batting average of .255 with an on-base percentage of .319.
• Including all qualified hitters, he ranks 70th in batting average, 86th in on-base percentage and 71st in slugging percentage.
• Kody Clemens has 115 hits, a team-high for the Twins.
• Luke Keaschall paces his team with a .365 on-base percentage.

Guardians vs Twins Head to Head

• 9/11/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/23/2026: 3-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/22/2026: 10-6 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/21/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/20/2026: 13-4 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/9/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/8/2026: 6-5 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/7/2026: 3-1 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/10/2026: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/8/2026: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)

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