Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 10:12 p.m.

Saturday's slate in the MLB includes a matchup between the Cleveland Guardians and the Minnesota Twins.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Twins Game Info

• Cleveland Guardians (74-73) vs. Minnesota Twins (69-77)
• Date: Saturday, September 12, 2026
• Time: 4:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: Twins.TV and CleGuardians.TV

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-116) | MIN: (-102)
• Spread: CLE: -1.5 (+138) | MIN: +1.5 (-166)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 13-7, 3.78 ERA vs Connor Prielipp (Twins) - 4-7, 5.25 ERA

The Guardians will give the nod to Gavin Williams (13-7) versus the Twins and Connor Prielipp (4-7). When Williams starts, his team is 14-14-0 against the spread this season. Williams' team is 14-9 this season when he starts and they are the moneyline favorite. The Twins have gone 10-9-0 against the spread when Prielipp starts. The Twins have been the underdog on the moneyline in 14 of Prielipp's starts this season, and they went 3-11 in those games.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (51.8%)

Guardians vs Twins Moneyline

• The Guardians vs Twins moneyline has Cleveland as a -116 favorite, while Minnesota is a -102 underdog at home.

Guardians vs Twins Spread

• The Guardians are at the Twins and are favored by 1.5 runs (+138 to cover) on the runline. Minnesota is -166 to cover.

Guardians vs Twins Over/Under

• The over/under for the Guardians versus Twins game on Sept. 12 has been set at 7.5, with -115 odds on the over and -105 odds on the under.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have been chosen as favorites in 83 games this year and have walked away with the win 42 times (50.6%) in those games.
• This year Cleveland has won 40 of 77 games when listed as at least -116 on the moneyline.
• The Guardians and their opponents have hit the over in 68 of their 139 games with a total set by oddsmakers this season.
• The Guardians have posted a record of 65-74-0 against the spread this season.
• The Twins have compiled a 38-48 record in games they were the underdog on the moneyline (winning 44.2% of those games).
• Minnesota has gone 37-44 when it has played as a moneyline underdog with odds of -102 or longer (45.7%).
• The Twins have played in 142 games with a set over/under, and have combined with opponents to go over the total 80 times (80-59-3).
• The Twins have gone 77-65-0 ATS this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland in total hits (133) this season while batting .296 with 45 extra-base hits. He has an on-base percentage of .365 and a slugging percentage of .464.
• Among all qualifying hitters, he ranks ninth in batting average, his on-base percentage ranks 23rd, and he is 37th in slugging.
• Jose Ramirez has 24 doubles, 11 home runs and 57 walks. He's batting .234 and slugging .371 with an on-base percentage of .326.
• Among qualifiers, he is 108th in batting average, 72nd in on-base percentage and 116th in slugging percentage.
• Steven Kwan leads the Guardians with an OPS of .708. He has a slash line of .275/.371/.336 this season.
• Kwan has recorded at least one base hit in four games in a row. During his last five outings he is hitting .318 with three doubles.
• Brayan Rocchio has been key for Cleveland with 121 hits, an OBP of .305 plus a slugging percentage of .376.

Twins Player Leaders

• Brooks Lee has 23 doubles, three triples, 23 home runs and 34 walks while batting .248. He's slugging .435 with an on-base percentage of .297.
• Including all the qualified hitters in the big leagues, his batting average ranks 81st, his on-base percentage is 121st, and he is 56th in slugging.
• Josh Bell leads his team with a .425 slugging percentage. He has a batting average of .256 with an on-base percentage of .319.
• Including all qualified hitters, his batting average places him 67th, his on-base percentage ranks 86th, and he is 67th in slugging.
• Kody Clemens has 113 hits, a team-high for the Twins.
• Luke Keaschall has a .368 on-base percentage to pace his team.

Guardians vs Twins Head to Head

• 7/23/2026: 3-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/22/2026: 10-6 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/21/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/20/2026: 13-4 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/9/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/8/2026: 6-5 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/7/2026: 3-1 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/10/2026: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/8/2026: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/21/2025: 6-2 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)

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