Cubs vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 9:12 p.m.

The MLB's Saturday slate includes the Chicago Cubs taking on the Pittsburgh Pirates.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Pirates Game Info

• Chicago Cubs (82-66) vs. Pittsburgh Pirates (74-74)
• Date: Saturday, September 12, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and SportsNet PT

Cubs vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-122) | PIT: (+104)
• Spread: CHC: -1.5 (+155) | PIT: +1.5 (-188)
• Total: 8.5 -- Over: (-134) | Under: (+110)

Cubs vs Pirates Probable Starting Pitchers

Probable Pitchers: Clay Holmes (Cubs) - 6-7, 2.83 ERA vs Paul Skenes (Pirates) - 10-11, 3.83 ERA

The probable pitchers are Clay Holmes (6-7) for the Cubs and Paul Skenes (10-11) for the Pirates. Holmes and his team are 6-9-0 ATS this season when he starts. When Holmes starts a game and his team is the favorite on the moneyline, they have a record of 5-5. The Pirates are 9-20-0 against the spread when Skenes starts. The Pirates have been the underdog on the moneyline in five of Skenes' starts this season, and they went 2-3 in those games.

Cubs vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (53%)

Cubs vs Pirates Moneyline

• Pittsburgh is a +104 underdog on the moneyline, while Chicago is a -122 favorite at home.

Cubs vs Pirates Spread

• The Cubs are hosting the Pirates and are favored by 1.5 runs on the spread. The Cubs are +155 to cover the runline, with the Pirates being -188.

Cubs vs Pirates Over/Under

• Cubs versus Pirates on Sept. 12 has an over/under of 8.5 runs, with the odds on the over -134 and the under set at +110.

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Cubs vs Pirates Betting Trends

• The Cubs have been victorious in 54, or 56.8%, of the 95 contests they have been chosen as favorites in this season.
• This season Chicago has been victorious 42 times in 77 chances when named as a favorite of at least -122 on the moneyline.
• The Cubs and their opponents have gone over in 80 of their 143 games with a total set by sportsbooks this season.
• The Cubs have posted a record of 69-74-0 against the spread this season.
• The Pirates have won 44.1% of the games this season they were the underdog on the moneyline (30-38).
• Pittsburgh has a 20-27 record (winning 42.6% of its games) when playing as a moneyline underdog of +104 or longer.
• The Pirates have played in 146 games with an over/under set, and have combined with opponents to go over the total 76 times (76-66-4).
• The Pirates have collected a 70-76-0 record ATS this season.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in OBP (.376), slugging percentage (.570) and total hits (160) this season. He has a .281 batting average.
• Among the qualified batters in the majors, his batting average ranks 23rd, his on-base percentage ranks ninth, and he is second in slugging.
• Crow-Armstrong has recorded at least one hit in nine straight games. During his last 10 outings he is hitting .263 with a double, three home runs, six walks and seven RBIs.
• Alex Bregman is batting .263 with 30 doubles, a triple, 25 home runs and 71 walks. He's slugging .449 with an on-base percentage of .351.
• Among qualifiers, he is 56th in batting average, 38th in on-base percentage and 47th in slugging percentage.
• Bregman brings a two-game streak with at least one hit into this matchup. In his last five games he is batting .353 with two doubles, a home run, three walks and three RBIs.
• Seiya Suzuki is batting .270 with a .480 slugging percentage and 81 RBI this year.
• Nico Hoerner has eight home runs, 66 RBI and a batting average of .267 this season.
• Hoerner heads into this matchup on a three-game hitting streak. During his last five outings he is batting .286 with a double and two RBIs.

Pirates Player Leaders

• Bryan Reynolds has a team-best .370 on-base percentage. He's batting .265 and slugging .431.
• Including all qualifying hitters, he is 52nd in batting average, while his on-base percentage ranks 15th and he is 59th in slugging.
• Brandon Lowe's 138 hits pace his team. He has a batting average of .257 while slugging .476 with an on-base percentage of .326.
• Including all qualified hitters, he is 66th in batting average, 72nd in on-base percentage and 27th in slugging percentage.
• Nick Gonzales has a .392 slugging percentage, which leads the Pirates.
• Ryan O'Hearn has 15 doubles, 17 home runs and 31 walks while batting .269.

Cubs vs Pirates Head to Head

• 9/11/2026: 12-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/26/2026: 8-7 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/25/2026: 11-0 CHC (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 3-2 CHC (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/28/2026: 7-2 CHC (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/27/2026: 10-4 CHC (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/26/2026: 12-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/25/2026: 2-1 PIT (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/12/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 12.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/11/2026: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)

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