Grizzlies vs. Pelicans Prediction, Odds, Picks, Best Bets for Oct. 22

Grizzlies vs. Pelicans Game Info

• Date: Wednesday, October 22, 2025
• Time: 8 p.m. ET
• Venue: FedExForum -- Memphis, Tennessee
• Coverage: FDSSE, Gulf Coast Sports, WVUE, and Pelicans+

The Memphis Grizzlies host the New Orleans Pelicans at FedExForum in the 2025-26 opener for both squads, starting at 8 p.m. ET on Wednesday, October 22, 2025. The Pelicans are 4.5-point underdogs in the game. The matchup has a point total of 236.5.

Grizzlies vs. Pelicans Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Grizzlies vs. Pelicans Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Grizzlies win (88.1%)

Grizzlies vs. Pelicans Betting Trends

• The Grizzlies put together a 41-38-3 ATS record last year.
• Against the spread, as underdogs of 4.5 points or more, the Pelicans went 21-31-1 last season.
• The Grizzlies and their opponents combined to go over the point total 47 out of 82 times last season.
• Last season, 45 of the Pelicans' 82 games hit the over.
• Memphis owned a worse record against the spread in home games (19-21-1) than it did in away games (22-17-2) last season.
• Against the spread, New Orleans performed better at home (21-18-2) than away (12-29-0) last season.

Grizzlies Leaders

• Jaren Jackson Jr.'s numbers last season were 22.2 points, 5.6 boards and 2 assists per game. He also drained 48.8% of his shots from the floor and 37.5% from beyond the arc, with an average of 2 triples.
• Last season, Ja Morant recorded an average of 23.2 points, 4.1 boards and 7.3 assists per game.
• Scotty Pippen Jr.'s stats last season included 9.9 points, 3.3 boards and 4.4 assists per game. He sank 48% of his shots from the floor and 39.7% from beyond the arc, with an average of 1.1 treys.
• Santi Aldama put up 12.5 points, 6.4 rebounds and 2.9 assists. He made 48.3% of his shots from the field and 36.8% from beyond the arc, with 1.8 treys per contest.
• Zach Edey's stats last season included 9.2 points, 8.3 rebounds and 1 assists per contest. He sank 58% of his shots from the floor.

Pelicans Leaders

• Jordan Poole's numbers last season were 20.5 points, 3 boards and 4.5 assists per contest, shooting 43.3% from the field and 37.8% from downtown, with an average of 3.5 made 3-pointers (fourth in league).
• Trey Murphy III put up 21.2 points, 5.1 boards and 3.5 assists last year. At the other end, he put up 1.1 steals and 0.7 blocked shots.
• Yves Missi averaged 9.1 points, 8.2 rebounds and 1.4 assists. At the other end, he posted 0.5 steals and 1.3 blocked shots.
• Zion Williamson recorded 24.6 points, 5.3 assists and 7.2 rebounds.
• Jose Alvarado averaged 10.3 points, 2.4 boards and 4.6 assists, shooting 39.2% from the floor and 35.9% from downtown, with 2 made treys per contest.

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