Giants vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 29

Odds updated as of 9:11 p.m.

The San Francisco Giants versus the San Diego Padres is on the MLB schedule for Tuesday.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Giants vs Padres Game Info

• San Francisco Giants (19-10) vs. San Diego Padres (17-11)
• Date: Tuesday, April 29, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and NBCS-BA

Giants vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-124) | SD: (+106)
• Spread: SF: -1.5 (+140) | SD: +1.5 (-172)
• Total: 6.5 -- Over: (-122) | Under: (-100)

Giants vs Padres Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 3-1, 1.98 ERA vs Nicholas Pivetta (Padres) - 4-1, 1.20 ERA

The Giants will give the ball to Logan Webb (3-1, 1.98 ERA), who is eyeing win No. 4 on the season, and the Padres will turn to Nicholas Pivetta (4-1, 1.20 ERA). Webb's team is 4-2-0 against the spread in his starts this season. When Webb starts a game and his team is the favorite on the moneyline, they have a record of 3-2. The Padres have a 4-1-0 ATS record in Pivetta's five starts with a set spread. The Padres were the underdog on the moneyline for two Pivetta starts this season -- they split the games.

Giants vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (55.1%)

Giants vs Padres Moneyline

• The Giants vs Padres moneyline has San Francisco as a -124 favorite, while San Diego is a +106 underdog at home.

Giants vs Padres Spread

• The Padres are at +1.5 on the runline against the Giants. The Padres are -172 to cover the spread, and the Giants are +140.

Giants vs Padres Over/Under

• The over/under for Giants-Padres on April 29 is 6.5. The over is -122, and the under is -100.

Bet on San Francisco Giants vs. San Diego Padres on FanDuel today!

Giants vs Padres Betting Trends

• The Giants have won in 13, or 72.2%, of the 18 contests they have been named as odds-on favorites in this year.
• This season San Francisco has been victorious 10 times in 15 chances when named as a favorite of at least -124 on the moneyline.
• The Giants' games have gone over the total in 16 of their 29 opportunities.
• The Giants are 14-15-0 against the spread in their 29 games with a line set by sportsbooks this season.
• The Padres have been the underdog on the moneyline 13 total times this season. They've gone 6-7 in those games.
• San Diego has gone 4-5 when playing as a moneyline underdog with odds of +106 or longer (44.4%).
• In the 28 games bookmakers have set an over/under for the Padres, they have combined with opponents to go over the total 10 times (10-17-1).
• The Padres have collected a 15-13-0 record ATS this season (covering 53.6% of the time).

Giants Player Leaders

• Jung Hoo Lee leads San Francisco with 35 hits and a team-best slugging percentage of .546. He's batting .324 with an on-base percentage of .383.
• Among qualifying batters in baseball, he is ninth in batting average, 24th in on-base percentage, and 16th in slugging.
• Lee has recorded at least one hit in five games in a row. During his last five outings he is hitting .368 with a double, two walks and an RBI.
• Wilmer Flores is batting .248 with seven home runs and seven walks, while slugging .455 with an on-base percentage of .303.
• His batting average is 75th among qualified players, his on-base percentage 102nd, and his slugging percentage 50th.
• Matt Chapman is batting .214 with a .408 slugging percentage and 16 RBI this year.
• Michael Yastrzemski leads San Francisco in OBP (.394) this season, fueled by 23 hits.
• Yastrzemski heads into this game on a two-game hitting streak. During his last five outings he is hitting .250 with a home run, a walk and two RBI.

Padres Player Leaders

• Fernando Tatis Jr. has accumulated a team-high OBP (.415) and slugging percentage (.625), and leads the Padres in hits (36, while batting .346).
• Including all the qualifying hitters in the big leagues, his batting average puts him fifth, his on-base percentage is seventh, and he is fourth in slugging.
• Tatis brings a three-game hitting streak into this matchup. During his last five outings he is hitting .333 with two doubles, a walk and an RBI.
• Manny Machado is batting .272 with 10 doubles, two home runs and 10 walks. He's slugging .427 with an on-base percentage of .333.
• His batting average ranks 49th among all qualified players, his on-base percentage is 64th, and he is 63rd in slugging.
• Luis Arraez is hitting .287 with three doubles, three home runs and five walks.
• Xander Bogaerts is hitting .242 with eight doubles and 13 walks.

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