Giants vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 4:12 a.m.

In MLB action on Tuesday, the San Francisco Giants play the St. Louis Cardinals.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Giants vs Cardinals Game Info

• San Francisco Giants (60-85) vs. St. Louis Cardinals (72-73)
• Date: Tuesday, September 8, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Cardinals.TV

Giants vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-112) | STL: (-104)
• Spread: SF: +1.5 (-178) | STL: -1.5 (+146)
• Total: 8 -- Over: (-105) | Under: (-115)

Giants vs Cardinals Probable Starting Pitchers

Probable Pitchers: Landen Roupp (Giants) - 8-13, 4.17 ERA vs Quinn Mathews (Cardinals) - 1-2, 4.38 ERA

The probable pitchers are Landen Roupp (8-13) for the Giants and Quinn Mathews (1-2) for the Cardinals. When Roupp starts, his team is 9-18-0 against the spread this season. Roupp's team has won 12.5% of his starts when they are favored on the moneyline (1-7). When Mathews starts, the Cardinals have gone 2-3-0 against the spread. The Cardinals are 1-3 in Mathews' four starts this season that they were the underdog on the moneyline.

Giants vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (52.5%)

Giants vs Cardinals Moneyline

• St. Louis is a -104 underdog on the moneyline, while San Francisco is a -112 favorite at home.

Giants vs Cardinals Spread

• The Cardinals are 1.5-run favorites against the spread for this matchup with the Giants. The Cardinals are +146 to cover, while the Giants are -178 to cover as a 1.5-run underdog on the runline.

Giants vs Cardinals Over/Under

• An over/under of 8 has been set for Giants-Cardinals on Sept. 8, with the over being -105 and the under -115.

Bet on San Francisco Giants vs. St. Louis Cardinals on FanDuel today!

Giants vs Cardinals Betting Trends

• The Giants have been victorious in 21, or 46.7%, of the 45 contests they have been chosen as favorites in this season.
• San Francisco has a record of 20-20 when favored by -112 or more this year.
• The Giants and their opponents have gone over in 68 of their 142 games with a total set by sportsbooks this season.
• The Giants have posted a record of 67-75-0 against the spread this season.
• The Cardinals have won 44 of the 95 games they were the underdog on the moneyline this season (46.3%).
• St. Louis has a 40-46 record (winning 46.5% of its games) when playing as a moneyline underdog of -104 or longer.
• In the 141 games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 64 times (64-70-7).
• The Cardinals have a 77-64-0 record ATS this season (covering 54.6% of the time).

Giants Player Leaders

• Rafael Devers leads San Francisco with 142 hits and an OBP of .342, plus a team-best slugging percentage of .522. He's batting .260.
• Among qualified hitters, he is 62nd in batting average, his on-base percentage ranks 51st, and he is ninth in slugging.
• Devers has recorded at least one hit in four games in a row. In his last five games he is hitting .421 with four doubles, three home runs, three walks and nine RBIs.
• Jung Hoo Lee has 28 doubles, four triples, nine home runs and 27 walks. He's batting .280 and slugging .406 with an on-base percentage of .323.
• Among qualified hitters, his batting average ranks him 25th, his on-base percentage 83rd, and his slugging percentage 86th.
• Lee takes a two-game streak with at least one hit into this contest. In his last five games he is batting .150 with a double, a walk and three RBIs.
• Bryce Eldridge is batting .265 with a .451 slugging percentage and 48 RBI this year.
• Eldridge has recorded a hit in four games in a row. During his last five outings he is batting .294 with three doubles, four walks and three RBIs.
• Drew Gilbert has been key for San Francisco with 72 hits, an OBP of .319 plus a slugging percentage of .369.

Cardinals Player Leaders

• Alec Burleson is batting .283 with 34 doubles, a triple, 22 home runs and 48 walks. He's slugging .467 with an on-base percentage of .344.
• Including all the qualified hitters in the majors, he ranks 16th in batting average, 47th in on-base percentage and 34th in slugging percentage.
• Burleson takes a four-game hitting streak into this matchup. In his last five games he is batting .273 with a double, a home run and three RBIs.
• Jordan Walker's 157 hits and .494 slugging percentage both lead his team. He has a batting average of .284 with an on-base percentage of .340.
• He ranks 14th in batting average, 52nd in on-base percentage and 16th in slugging percentage in the majors.
• Ivan Herrera a has .362 on-base percentage to lead the Cardinals.
• Nathan Church is hitting .243 with 12 doubles, two triples, 10 home runs and 21 walks.

Giants vs Cardinals Head to Head

• 9/7/2026: 5-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/24/2025: 4-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/23/2025: 9-8 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/22/2025: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/7/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 3-2 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 6-1 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/28/2024: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2024: 6-3 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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