Duke vs Notre Dame College Basketball Prediction, Odds, Picks, Best Bets for Feb. 24

The Duke Blue Devils (25-2, 13-1 ACC) will look to build on a four-game winning streak when they visit the Notre Dame Fighting Irish (12-15, 3-11 ACC) on February 24, 2026 at Purcell Pavilion.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Notre Dame Game Info and Odds

• Game day: Tuesday, February 24, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: South Bend, Indiana
• Arena: Purcell Pavilion

If you plan to place a wager on Duke-Notre Dame outing (in which Duke is a 17.5-point favorite and the over/under has been set at 141.5 points), below are a few betting insights and trends for Tuesday's game.

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Duke vs. Notre Dame: ATS Betting Stats and Trends

• Duke has put together a 14-13-0 record against the spread this season.
• Notre Dame is 13-13-0 ATS this year.
• Duke (5-5) covers a lower percentage of games when it is favored by 17.5 points or more this season (50%) than Notre Dame (1-0) does as a 17.5+-point underdog (100%).
• At home, the Blue Devils own a worse record against the spread (5-8-0) compared to their ATS record on the road (6-3-0).
• Against the spread, the Fighting Irish have had better results away (6-4-0) than at home (6-7-0).
• Duke has beaten the spread seven times in 14 conference games.
• Against the spread in ACC play, Notre Dame is 6-8-0 this year.

Duke vs. Notre Dame: Moneyline Betting Stats

• Duke has been chosen as the moneyline favorite in 20 games this year and has walked away with the win 18 times (90%) in those games.
• The Blue Devils have yet to lose in four games when named as moneyline favorite of -3030 or better.
• Notre Dame has won 18.8% of the games this season it was the underdog on the moneyline (3-13).
• The Fighting Irish have played as a moneyline underdog of +1200 or longer in only one game this season, which they lost.
• The moneyline set for this matchup implies Duke has a 96.8% chance of walking away with the win.

Duke vs. Notre Dame Head-to-Head Comparison

• Duke was the 11th-best squad in the nation in points scored (83.2 per game) and seventh-best in points allowed (62.8) last season.
• Duke was the 24th-best team in the nation in rebounds per game (35.6) and 12th-best in rebounds allowed (27.3) last season.
• Duke was 17th-best in the nation in assists (16.9 per game) last year.
• Last season, Duke was ninth-best in college basketball in turnovers committed (8.9 per game) and ranked 265th in turnovers forced (10.4).
• Offensively, Notre Dame averaged 72.6 points per game (212th-ranked in college basketball) last season. It gave up 72.5 points per contest at the other end of the court (195th-ranked).
• Last season Notre Dame averaged 31.6 rebounds per game (194th-ranked in college basketball) and allowed 29.1 rebounds per contest (56th-ranked).
• Notre Dame delivered 11.4 assists per game, which ranked them 323rd in the nation.
• Notre Dame ranked 98th in college basketball at 10.3 turnovers per game, but it forced 9.5 turnovers per game, which ranked 25th-worst in college basketball.

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