Duke vs Cal Prediction, Odds, Picks, Best Bets for Week 6 2025

College football's Saturday schedule includes the Duke Blue Devils facing the California Golden Bears.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Duke vs Cal Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Duke: (-152) | Cal: (+128)
• Spread: Duke: -2.5 (-122) | Cal: +2.5 (100)
• Total: 54.5 -- Over: (-115) | Under: (-105)

Duke vs Cal Betting Trends

• Duke has won twice against the spread this season.
• Duke has two wins ATS (2-1) as a 2.5-point or higher favorite in 2025.
• This season, four of Duke's five games have gone over the point total.
• Cal has beaten the spread three times in five games.
• Cal has covered every time (2-0) as a 2.5-point or greater underdog this season.
• Cal and its opponent have yet to hit the over this season.

Duke vs Cal Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Golden Bears win (50.8%)

Duke vs Cal Point Spread

Duke is a 2.5-point favorite against Cal. Duke is -122 to cover the spread, and Cal is +100.

Duke vs Cal Over/Under

A total of 54.5 points has been set for the Duke-Cal matchup on Oct. 4, with the over available at -115 and the under at -105.

Duke vs Cal Moneyline

Duke is a -152 favorite on the moneyline, while Cal is a +128 underdog.

Duke vs. Cal Points Insights

Duke vs. Cal Game Info

• Game day: Saturday, October 4, 2025
• Game time: 10:30 p.m. ET
• TV channel: ESPN
• Location: Berkeley, California
• Stadium: California Memorial Stadium

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Check out even more in-depth Duke vs. Cal analysis on FanDuel Research.