Duke vs Cal Prediction, Odds, Picks, Best Bets for Week 6 2025

Saturday's slate in college football includes a matchup between the Duke Blue Devils and the California Golden Bears.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Duke vs Cal Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Duke: (-146) | Cal: (+122)
• Spread: Duke: -2.5 (-120) | Cal: +2.5 (-102)
• Total: 56.5 -- Over: (-105) | Under: (-115)

Duke vs Cal Betting Trends

• Duke has two wins against the spread this year.
• As at least a 2.5-point favorite, Duke has two wins ATS (2-1).
• There have been four Duke games (of five) that hit the over this year.
• Cal has beaten the spread three times in five games.
• Cal has yet to lose ATS (2-0) as a 2.5-point underdog or more this year.
• No Cal game has gone over the point total this season.

Duke vs Cal Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Golden Bears win (50.4%)

Duke vs Cal Point Spread

Duke is favored by 2.5 points (-120 to cover) in this matchup. Cal, the underdog, is -102.

Duke vs Cal Over/Under

The Duke-Cal game on Oct. 4 has been given an over/under of 56.5 points. The over is -105 and the under is -115.

Duke vs Cal Moneyline

The Duke vs Cal moneyline has Duke as a -146 favorite, while Cal is a +122 underdog.

Duke vs. Cal Points Insights

Duke vs. Cal Game Info

• Game day: Saturday, October 4, 2025
• Game time: 10:30 p.m. ET
• TV channel: ESPN
• Location: Berkeley, California
• Stadium: California Memorial Stadium

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Check out even more in-depth Duke vs. Cal analysis on FanDuel Research.