Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for NL Wild Card Game 2 on Oct. 1

Odds updated as of 11:11 p.m.

On Wednesday in the MLB, the Chicago Cubs are up against the San Diego Padres in Game 2 of the NL Wild Card Series.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Padres Game Info

• Chicago Cubs (92-70) vs. San Diego Padres (90-72)
• Date: Wednesday, October 1, 2025
• Time: 3:08 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: ABC

Cubs vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-112) | SD: (-104)
• Spread: CHC: +1.5 (-215) | SD: -1.5 (+176)
• Total: 6.5 -- Over: (-122) | Under: (-100)

Cubs vs Padres Probable Starting Pitchers

Probable Pitchers: Andrew Kittredge (Cubs) - 4-3, 3.40 ERA vs Dylan Cease (Padres) - 8-12, 4.55 ERA

The Cubs will call on Andrew Kittredge (4-3, 3.40 ERA) versus the Padres and Dylan Cease (8-12, 4.55 ERA). Kittredge did not pitch in a game with a spread last season. Kittredge did not pitch as the moneyline favorite last season. The Padres have gone 14-18-0 ATS in Cease's 32 starts with a set spread. The Padres are 3-5 in Cease's eight starts this season that they were the underdog on the moneyline.

Cubs vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (53.6%)

Cubs vs Padres Moneyline

• Chicago is a -112 favorite on the moneyline, while San Diego is a -104 underdog on the road.

Cubs vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Cubs. The Padres are +176 to cover, while the Cubs are -215 to cover as a 1.5-run underdog on the runline.

Cubs vs Padres Over/Under

• A combined run total of 6.5 has been set for Cubs-Padres on Oct. 1, with the over at -122 and the under at -100.

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Cubs vs Padres Betting Trends

• The Cubs have won in 71, or 65.1%, of the 109 contests they have been named as odds-on favorites in this year.
• Chicago has a record of 71-38 in contests when oddsmakers favor them by -112 or more on the moneyline.
• The Cubs' games have gone over the total in 74 of their 158 opportunities.
• In 158 games with a line this season, the Cubs have a mark of 76-82-0 against the spread.
• The Padres are 33-35 in games they were listed as the moneyline underdog (winning 48.5% of those games).
• San Diego has a record of 30-34 when it has played as a moneyline underdog with odds of -104 or longer (46.9%).
• In the 161 games oddsmakers have set an over/under for the Padres, they have combined with opponents to go over the total 70 times (70-88-3).
• The Padres have put together an 87-74-0 record against the spread this season (covering 54% of the time).

Cubs Player Leaders

• Kyle Tucker has 133 hits this season and a team-best OBP of .377. He has a .266 batting average and a slugging percentage of .464.
• Among all qualifying hitters in baseball, he ranks 46th in batting average, seventh in on-base percentage, and 44th in slugging.
• Nico Hoerner has an OPS of .739, fueled by an OBP of .345 and a team-best slugging percentage of .394 this season. He's batting .297.
• Among all qualified, he is eighth in batting average, 46th in on-base percentage and 110th in slugging percentage.
• Hoerner heads into this game looking to extend his two-game hit streak. During his last five outings he is batting .238 with a home run and two RBIs.
• Pete Crow-Armstrong has collected 146 base hits, an OBP of .287 and a slugging percentage of .481 this season.
• Seiya Suzuki is batting .245 with a .326 OBP and 103 RBI for Chicago this season.
• Suzuki has hit safely in eight straight games. During his last 10 outings he is batting .281 with a double, six home runs, four walks and 13 RBIs.

Padres Player Leaders

• Fernando Tatis Jr. has a team-best .368 on-base percentage. He's batting .268 and slugging .446.
• Including all qualified hitters in the majors, he is 43rd in batting average, 10th in on-base percentage and 60th in slugging percentage.
• Manny Machado paces his team with 169 hits. He has a batting average of .275 while slugging .460 with an on-base percentage of .335.
• His batting average ranks 33rd among all qualified players, his on-base percentage is 58th, and he is 49th in slugging.
• Luis Arraez has a .392 slugging percentage, which paces the Padres.
• Ryan O'Hearn is batting .281 with 21 doubles, a triple, 17 home runs and 58 walks.

Cubs vs Padres Head to Head

• 9/30/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/16/2025: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/15/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/14/2025: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/6/2025: 8-7 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/4/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/8/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/7/2024: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/6/2024: 6-3 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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