Colorado State vs Wyoming Prediction, Odds, Picks, Best Bets for Week 1 2026

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The Saturday schedule in college football includes a matchup between the Colorado State Rams and the Wyoming Cowboys.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Colorado State vs Wyoming Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Colorado State: (-156) | Wyoming: (+130)
Spread: Colorado State: -3.5 (100) | Wyoming: +3.5 (-122)
Total: 46.5 -- Over: (-105) | Under: (-115)

Colorado State's record against the spread last season was 4-8-0.
Colorado State went winless ATS (0-2) when playing as at least 3.5-point favorites last year.
Last season, five of Colorado State's 12 games hit the over.
Wyoming had five wins in 12 games against the spread last year.
Wyoming won once ATS (1-5) as underdogs of 3.5 points or more last season.
Two of Wyoming's 12 games last season hit the over.

All college football win probability predictions and picks are according to numberFire.
Prediction: Rams win (52.7%)

Wyoming is a 3.5-point underdog against Colorado State. Wyoming is -122 to cover the spread, and Colorado State is +100.

The over/under for Colorado State-Wyoming on Sept. 5 is 46.5. The over is -105, and the under is -115.

Wyoming is the underdog, +130 on the moneyline, while Colorado State is a -156 favorite.

The Rams' average implied point total last season was 5.7 more points than their implied total in Saturday's game (30.7 implied points on average compared to 25 implied points in this game).
The Cowboys' average implied point total last season (27.7 points) is 5.7 points higher than their implied total in this matchup (22 points).

Check out even more in-depth Colorado State vs. Wyoming analysis on FanDuel Research.

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